Evidence map›Paper›PMID 41044550›Full record

ArticleBMC pediatrics2025

The association between foot morphological development and bone maturation in children: a cross-sectional study.

Si-Yuan Xie, Xiao Li, Zi-Yu Feng, Jing-Yi She, Yin Xie, Xin-Yao Hu, Jian-You Li, Kai-Rui Zhang, Hua-Jun Wang, Qi-Wei Pan and 8 more

Abstract read
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Si-Yuan Xie *School of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.ORCID 0009-0002-5403-118X
Xiao Li *School of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Zi-Yu Feng *School of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.ORCID 0000-0002-7716-9934
Jing-Yi SheSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Yin XieSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Xin-Yao HuInstitute of Human Factors and Ergonomics, College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, China.
Jian-You LiDepartment of Orthopedics, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Zhejiang University Huzhou Hospital, Huzhou, 313000, China.
Kai-Rui ZhangDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hua-Jun WangDepartment of Bone and Joint Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510515, China.
Qi-Wei PanSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Jun-Jie CaoSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Tian-Yi LiSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Hao-Yong HongSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Yi-Ling HeSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Chen-Zhe GaoSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.
Fu-Hui LinDepartment of Orthopedics, Shenzhen Pingle Orthopedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, 518000, China.
Yi-Kai LiSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China.ORCID 0000-0003-0766-6051
Chao ChenSchool of Traditional Chinese Medicine, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, China. chenchao@smu.edu.cn.ORCID 0000-0001-8576-7427

Funding

Administration of Traditional Chinese Medicine of Guangdong Province, China No. 20241199National Natural Science Foundation of China No. 82374605
6 · The paper itself

Abstract

purposeAccurate assessment of pediatric foot development is essential for guiding clinical interventions. While chronological age (CA) is commonly used, it may not account for individual variations influenced by skeletal maturity. This study hypothesizes that bone age (BA) correlates more strongly with foot morphology than CA, particularly in predicting pediatric flatfoot progression.

methodsA retrospective cross-sectional study was conducted with 141 healthy children aged 9-13 years. BA was assessed via hand-wrist X-rays (China 05 RUS-CHN method), and 3D foot parameters were measured using laser scanning. Participants were categorized into delayed, normal, and advanced maturity groups based on BA-CA differences. Correlation analyses and principal component analysis (PCA) were performed to evaluate associations between BA, CA, and foot morphology.

resultsBA exhibited stronger correlations with foot length (FL), outer ankle height (OAH), ball width (BW), and ball girth (BG) compared to CA. Stratified analyses revealed sex-specific differences, with BA-FL correlations in males (r = 0.722) surpassing females (r = 0.572). However, BA showed limited associations with arch morphology parameters (KY index [KYI] and arch height [AH]; |r| < 0.3). PCA further demonstrated that general foot size (PC1) correlated robustly with BA (r = 0.671), while arch morphology (PC2) remained independent of both BA and CA (r = -0.113).

conclusionBA is a superior predictor of foot size growth (e.g., FL, BW) compared to CA, particularly in males, but offers limited utility in assessing arch maturation. These findings suggest BA may enhance clinical foot size predictions, yet arch development likely depends on other factors beyond skeletal maturity. Integrating BA into pediatric flatfoot management requires careful consideration of its context-specific benefits and limitations.

Indexed as

Age Determination by SkeletonBone DevelopmentFootAdolescentChildCross-Sectional StudiesFemaleFlatfootHumansMaleRetrospective StudiesBone ageFlatfootFoot morphologyPediatric

Identifiers

PMID41044550
PMCPMC12495726

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