Evidence map›Paper›PMID 41044409›Full record

ArticleNature plants2025

Discovery of iridoid cyclase completes the iridoid pathway in asterids.

Maite Colinas, Chloée Tymen, Joshua C Wood, Anja David, Jens Wurlitzer, Clara Morweiser, Klaus Gase, Ryan M Alam, Gabriel R Titchiner, John P Hamilton and 6 more

Abstract read
In one paragraph

Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. TheHorticulture research · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maite ColinasDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany. mmartinez@ice.mpg.de.ORCID 0000-0001-7053-2983
Chloée TymenDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Joshua C WoodCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA.
Anja DavidDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Jens WurlitzerDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Clara MorweiserDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID 0009-0001-7657-8795
Klaus GaseDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID 0000-0002-8028-5645
Ryan M AlamDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID 0000-0002-0227-0771
Gabriel R TitchinerDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
John P HamiltonCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA.ORCID 0000-0002-8682-5526
Sarah HeinickeDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Ron P DirksFuture Genomics Technologies, Leiden, The Netherlands.
Adriana A LopesUniversidade de Ribeirão Preto, Departamento de Biotecnologia, Ribeirão Preto, Brazil.
Lorenzo CaputiDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
C Robin BuellCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA. Robin.Buell@uga.edu.ORCID 0000-0002-6727-4677
Sarah E O'ConnorDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany. oconnor@ice.mpg.de.ORCID 0000-0003-0356-6213

Funding

Multi-omics approaches to lower the barriers to sustainable production of plant natural products with relevance to human healthR01AT012783 · NCCIH · UNIVERSITY OF GEORGIA · PI Carol Robin Buell · 2024 to 2026
$1.5M
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 814645NCCIH NIH HHS R01 AT012783U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AT012783
6 · The paper itself

Abstract

Iridoids are specialized monoterpenes ancestral to asterid flowering plants

Indexed as

IridoidsPlant ProteinsBiosynthetic PathwaysPhylogenyIridoidsPlant Proteins

Identifiers

PMID41044409
PMCPMC12626888

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.