ArticleNature plants2025
Plant mobile domain protein-DNA motif modules counteract Polycomb silencing to stabilize gene expression.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Epigenetic Control of Cold Stress Tolerance in Plants: Emerging Mechanisms and Applications for Crop Improvement.International journal of molecular sciences · 2026Review
- Deciphering the dynamics of active autonomous terminal inverted repeat transposons in the plant kingdom.aBIOTECH · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
In plants and animals, Polycomb group proteins are crucial for development, regulating gene expression through the trimethylation of lysine 27 on histone H3 and subsequent gene silencing. While the specification of Polycomb silencing targets is increasingly understood, it remains unclear how certain genes with apparent silencing-attracting features escape this process. Here we show that the plant-mobile-domain-C-containing proteins MAINTENANCE OF MERISTEMS (MAIN), MAIN-LIKE 1 (MAIL1) and MAIL2 oppose Polycomb silencing at numerous actively transcribed genes in Arabidopsis. Mutations in MAIN, MAIL1 or MAIL2 result in Polycomb-group-dependent ectopic H3 K27 trimethylation, often associated with transcriptional repression. We show that MAIL1 (which functions in concert with MAIN) and MAIL2 target distinct gene sets and associate with chromatin at specific DNA sequence motifs. We demonstrate that the integrity of these motif sequences is essential for promoting expression and antagonizing H3 K27 trimethylation. Our results unveil a system opposing Polycomb silencing that involves plant mobile domain C protein-DNA motif modules, expanding our understanding of eukaryotic gene regulation mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.