ArticleNature plants2025
Retrieval from vacuolar and endosomal compartments underpinning the neofunctionalization of SNARE in plants.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- From EM to AI: Multiscale imaging of the secretory pathway with insights from plant cells.Journal of microscopy · 2026Review
- SNX-mediated biogenesis of a plant-unique vesicle derived from the multivesicular body.Nature communications · 2026Article
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9 authors.
Funding
Abstract
A distinctive protein and lipid composition underlies the distinct function of each organelle, regulated by balanced anterograde and retrograde membrane trafficking. The vacuole, the largest plant organelle, is pivotal in various plant functions, and its protein composition is tightly regulated by bidirectional trafficking. However, the existence of retrograde transport from the plant vacuole has remained unverified. Here we demonstrate retrograde trafficking from the vacuole in Arabidopsis. We observed the retrieval of VAMP727, a plant-unique vacuolar membrane fusion machinery, from the vacuolar membrane. VAMP727 retrieval is facilitated by sorting nexin proteins, which independently diversified between plant and non-plant systems. Furthermore, we show that the core retromer complex and sorting nexins act independently in distinct retrograde transport events with specific cargos. Plant cells have thus elaborated a unique retrieval mechanism from the vacuole, underpinning the neofunctionalization of VAMP727 during plant evolution.
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