ArticleJournal of exposure science & environmental epidemiology2026
Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort.
Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Epigenetic vulnerability in endocrine disruption: bridging mechanisms, models, and environmental inequities.Clinical epigenetics · 2026Review
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Authors and funding
17 authors.
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Abstract
backgroundThe biochemical dysregulation underlying the adverse health effects of exposure to air pollution (AP) remains unclear.
objectiveThe objective of this study was to explore associations between long-term exposure to AP and the urinary metabolome.
methodsIn the Swedish birth cohort BAMSE (n = 4089), urine samples were collected from a subset of participants attending clinical examination at the 4-year follow-up and from all participants attending clinical examination at the 24-year follow-up. Among paired samples and children with diagnosis of asthma and/or low lung function, non-targeted screening using liquid chromatography high-resolution mass spectrometry was applied to 4-year samples (n = 612) and 24-year samples (n = 846) and metabolites were annotated based on standard matching to in-house compound libraries (n = 260 metabolites). Time-weighted average exposure to air pollutants (i.e., particulate matter with diameter ≤10μm (PM
resultsAP exposure was overall positively associated with metabolite abundance (p < 0.002). However, metabolite-specific associations exhibited variability. At the 4-year follow-up, the first-year-of-life and prior-year AP exposures were positively associated with 8 purine/pyrimidine derivative metabolites (e.g., an increase of 2.8 μg/m IMPACT: Long-term exposure to air pollution alters urinary metabolites in children and young adults, revealing environmental impacts on systemic metabolism even at low levels of air pollution.
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