ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Challenges in pathological diagnosis of rare head and neck cancers: National survey and retrospective study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Basal cell adenocarcinoma of the parotid gland: prognostic factors and survival outcomes: a systematic review and pooled patient-level analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- The role of elective neck dissection in parotid acinic cell carcinoma: a systematic review.Oral and maxillofacial surgery · 2026Pooled it
- Two-year follow-up outcomes of neoadjuvant therapy in oral squamous cell carcinoma: an exploratory systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Immune-related hallmark pathway heterogeneity identifies a prognostic risk signature with independent external validation in glioblastoma.Discover oncology · 2026Article
- Historical Evolution of Terminology and Current Classification of Neuroendocrine Neoplasms of the Larynx and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNENs): A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Medullary thyroid carcinoma diagnosis based on microRNA analysis: a case report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Synchronous p16-Negative Oropharyngeal Squamous Cell Carcinoma and High-Grade Small-Cell Neuroendocrine Carcinoma of the Head and Neck: A Case Report.Reports (MDPI) · 2026Article
- Thyroid cancer risk in people living with HIV: a systematic review and meta-analysis of global population-based registry studies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Clinical Characteristics and Prognosis of Neuroendocrine Carcinoma in the Head and Neck: A Single-Institutional Retrospective Analysis.Current oncology (Toronto, Ont.) · 2026Article
- Evolving Landscape for Artificial Intelligence in the Diagnosis and Histopathologic Assessment of Oral and Oropharyngeal Cancer.Head and neck pathology · 2026Review
- Prognostic significance of PET/CT false-positive cervical lymph nodes in head and neck cancer.Scientific reports · 2026Article
- The neck matters: optimising lymph node management in laryngeal cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
- Delayed medical care experiences among patients with head and neck cancers: an exploratory study using patient journey mapping.BMC health services research · 2026Article
- Feasibility and role of the lateral arm free flap following pull-through oropharyngectomy for tonsillar carcinoma: a clinical analysis.BMC surgery · 2026Article
- Machine Learning Models for Individualized Osteoradionecrosis Risk Prediction in Head and Neck Cancer.Journal of medical systems · 2026Article
- Global Burden of Deep Neck Space Abscesses: Epidemiology, Challenges, and Outcomes.Journal of personalized medicine · 2026Review
- Platelet-to-high-density lipoprotein ratio predicts postoperative overall survival in hepatocellular carcinoma: a retrospective cohort study.World journal of surgical oncology · 2026Article
- Role of frailty in otorhinolaryngology and head and neck surgery in a secondary and a tertiary care center: a prospective observational two-cohort study.Scientific reports · 2026Observational
- A Hypoxia Associated STC2 High Endothelial Subpopulation is Linked to Lipid Metabolic Reprogramming, Pathological Angiogenesis, and Immune Remodeling in Head and Neck Squamous Cell Carcinoma.International journal of general medicine · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe complexity of head and neck cancers (HNC) makes histopathological diagnosis challenging, mainly for rare histotypes (r-HNCs) where a second opinion (2°op) is often required.
methodsIn 2023, the Italian Association of Head and Neck Oncology (AIOCC) young task force conducted a 17-item survey on HNC multidisciplinary management and pathological diagnosis. A retrospective review was performed on r-HNC cases evaluated in the last 10 years by an HNC expert pathologist at a referral center. Major diagnostic discrepancies (MDD), defined as changes in pathological diagnosis that significantly influenced clinical management, were analyzed.
resultsAmong the 30 surveyed participants, 67% sought a 2°op for r-HNC, often leading to changes in diagnosis or treatment. In 130 reviewed cases, 66% had no initial pathological diagnosis; of the remaining 34% (44) with a previous diagnosis, 50% were changed after the review. Minor salivary gland tumors of the oral cavity (57%) had the highest rate of MDD, followed by the sinonasal tract (43%). 14% (6) involved only descriptive diagnosis reformulation/reclassification whereas of MDD (16%,7), 29% involved a change from benign to malignant, 14% a change from malignant to benign.
conclusionsAccording to the complexity of HNC district, a second opinion is often needed and when a preliminary histopathological diagnosis was formulated, a MDD results in 16%. An effective diagnostic network among HNC pathologists is warranted.
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