SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Alginates and laryngopharyngeal reflux: where we stand. A systematic review.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Presentation, Health Care Burden, and Risk Stratification.Neurogastroenterology and motility · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLaryngopharyngeal reflux (LPR) is a medical condition in which gastric contents reflux, directly or indirectly, causing morphological and neurological alterations in the upper aerodigestive system. Alginates are a common solution to this problem.
methodsWe conducted a PRISMA-compliant systematic review of the MEDLINE (via PubMed), Cochrane Central Register for Controlled Trials, and Scopus databases without temporal limitations. Our goal was to gather all available data published in English on the use of alginates in patients with LPR.
resultsA total of 134 articles were screened, and 16 met the inclusion criteria. The included studies comprised three surveys, one experience study, four observational cohort studies, two cross-sectional studies, one case series, four experimental randomized studies, and one non-randomized study. The remaining 12 clinical studies enrolled a total of 994 individuals, including 274 patients with both LPR and dry eye syndrome in two of these studies. Three key themes emerged from the included texts: decision-making and awareness among clinicians treating patients with LPR regarding alginate use, the effect of alginates in treating LPR symptoms, the effect of alginates in patients with both LPR and dry eye syndrome. The main outcome measures in the clinical studies on LPR patients included RSS, RSA, RSI, RFS, symptom resolution, VAS scores, treatment tolerance, and drug-related adverse events.
conclusionAlginates demonstrate a beneficial role both as monotherapy and as adjunct therapy with proton pump inhibitors (PPIs). Larger randomized studies are needed to further define their effectiveness in treating LPR.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.