ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
The impact of bacterial lysate (OM-85) on clinical and immunological parameters in children with allergic rhinitis.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Editorial comment: Efficacy and safety of bacterial immunostimulants in immunodeficient individuals: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Laryngopharyngeal reflux disease, digestive enzymes and otitis media in pediatric populations.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the clinical efficacy and immunomodulatory effects of bacterial lysate (OM-85) in children with allergic rhinitis (AR).
methodA total of 40 children aged 5 to 14 years with AR were selected and divided into two groups: the control group (treated with mometasone furoate nasal spray and cetirizine) and the observation group (treated with the same regimen as the control group, plus OM-85). The changes in Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores, lymphocyte subsets, and serum immunoglobulin levels were compared before and after treatment between the two groups.
resultsAfter treatment, both groups showed a significant reduction in the frequency of allergic rhinitis episodes (P < 0.05). The RQLQ scores indicated that the observation group showed more significant improvements in daily activities, rhinitis-related behaviors, nasal symptoms, emotional responses, and overall score (P < 0.05), while the control group showed improvements in only some of the indicators (P < 0.05). In the observation group, NK cell levels (6.28% [3.46; 8.55] vs. 7.80% [5.90; 13.87], P = 0.025), Treg cell levels (0.83 ± 0.50% vs. 1.20 ± 0.47%, P = 0.016), serum IgA (0.97 ± 0.34 vs. 1.49 ± 0.58 g/L, P = 0.001), and IgG levels (9.32 ± 2.85 vs. 11.11 ± 2.09 g/L, P = 0.019) were significantly increased, while CD8 + T cell levels decreased (28.84 ± 5.24% vs. 25.62 ± 5.85%, P = 0.037). No significant changes in immune parameters were observed in the control group (P > 0.05).
conclusionOM-85 adjunctive therapy can enhance immune function, improve clinical symptoms, and enhance quality of life in children with allergic rhinitis.
Indexed as
Identifiers
41044378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.