Evidence map›Paper›PMID 41044284›Full record

ArticleSurgical endoscopy2026

Prolonged postoperative mechanical ventilation is associated with a decrease in anastomotic leak following esophagectomy.

Liang Zhang, Shulin Zhao, Taiming Zhang, Liang Chen, Chunshu Fang, Yingjian Wang, Tao Bao, Xianfeng Xie, Xu Chen, Wei Guo and 1 more

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liang Zhang *Department of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Shulin Zhao *Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Taiming ZhangDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Liang ChenDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Chunshu FangDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Yingjian WangDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Tao BaoDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Xianfeng XieDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Xu ChenDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China.
Wei GuoDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China. gyguowei@hotmail.com.
Kunkun LiDepartment of Thoracic Surgery, Daping Hospital, Army Medical University, Changjiang Route 10#, Daping, Chongqing, 400042, People's Republic of China. likunlee@126.com.

Funding

Chongqing Municipal Youth Science and Technology Talent Training Project 2023MSXM084Natural Science Foundation of Chongqing Municipality CSTB2023NSCQ-MSX0566
6 · The paper itself

Abstract

backgroundAnastomotic leak (AL) is a severe complication after minimally invasive esophagectomy (MIE). Oxygen therapy is expected to reduce its incidence. However, when and how to conduct oxygen therapy and whether it reduces anastomotic leak incidence is unclear.

methodWe retrospectively analyzed the oxygenation index (OI) of 75 patients with esophageal cancer after MIE in our hospital. Trends of OI changes were depicted. According to mechanical ventilation duration, patients were divided into Prolonged Postoperative Mechanical Ventilation (PPMV) (≥ 24 h) and Non-Prolonged Postoperative Mechanical Ventilation (NPMV) (< 24 h) groups. The effect of PPMV on OI was analyzed; the number of analyzable cases was expanded to 312, and 89 cases each of PPMV and NPMV were obtained by Propensity Score Matching (PSM). The incidences of AL and other complications were compared between the two groups.

resultsOI significantly decreased on POD1 and 2. OI in AL group was higher on POD1 and showed a more dramatic decrease on POD 2. Patients in PPMV group had a moderate OI decrease on POD 2 and lower AL rate. Expanding cases to 312, AL rate in PPMV group was significantly lower than NPMV group (8.08% vs 23.47%, p = 0.001). After PSM, the difference in AL rate remained significant (7.88% vs 24.71%, p = 0.004). The pulmonary infection and pleural effusion incidence was lower in PPMV group.

conclusionThe sharp decline of OI on POD 2 may cause AL following MIE. Prolonging postoperative mechanical ventilation to 24 h may help moderate the decline in OI and potentially reduce the incidence of anastomotic leakage.

Indexed as

Anastomotic LeakEsophageal NeoplasmsEsophagectomyPostoperative CareRespiration, ArtificialAgedFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesTime FactorsAnastomotic leakMinimally invasive esophagectomyOxygenation indexPostoperative mechanical ventilation

Identifiers

PMID41044284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.