Evidence map›Paper›PMID 41044282›Full record

Trial reportSurgical endoscopy2025

Efficacy and safety of three methods of endoscopic retrograde cholangiopancreatography in removing small common bile duct stones: a prospective multicenter randomized controlled study.

Qiang Ye, Jin Zhang, Jun Yao, Qiang Zhan, Lisheng Tao, Xiaobing Xu, Xinyun Qiu, Tao Chen, Jinliang Ni, Jingjing Ma and 4 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiang YeDepartment of Gastroenterology, Zhenjiang First Peoples Hospital, Zhenjiang, China.
Jin Zhang *Department of Respiratory, Zhenjiang First Peoples Hospital, Zhenjiang, China.
Jun YaoDepartment of Gastroenterology, Zhenjiang First Peoples Hospital, Zhenjiang, China.
Qiang ZhanDepartment of Gastroenterology, Wuxi Peoples Hospital, Wuxi, China.
Lisheng TaoDepartment of Gastroenterology, Zhenjiang First Peoples Hospital, Zhenjiang, China.
Xiaobing XuDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Xinyun QiuDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Tao ChenDepartment of Gastroenterology, Wuxi Peoples Hospital, Wuxi, China.
Jinliang NiDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Jingjing MaDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Lisha JiangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Guoxin ZhangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China.
Hong ZhuDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China. zhuhong1059@126.com.
Shunfu XuDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing, 210029, China. xushfu@126.com.

Funding

Science and Technology Bureau of Zhenjiang JSYC-2023-018Zhenjiang First People's Hospital Fund KFB2023008Zhenjiang First People's Hospital Fund YZ2023003
6 · The paper itself

Abstract

backgroundIn endoscopic retrograde cholangiopancreatography (ERCP), common bile duct stones (CBDSs) can be removed through strategies, including endoscopic sphincterotomy (EST), endoscopic papillary balloon dilation (EPBD), and endoscopic sphincterotomy plus balloon dilation (ESBD). By comparing the efficacy and safety of these three methods, we aimed to determine the optimal technique for the removal of small CBDSs (≤ 10 mm in size).

methodsThis was a multicenter, prospective, parallel controlled study involving patients with small CBDSs undergoing ERCP in three tertiary medical institutions in Jiangsu Province, China, who were randomly divided into the EST group, EPBD group, and ESBD group. The efficiencies of these three techniques were compared by analyzing the first-session and overall success rates of stone removal and the use of endoscopic mechanical lithotripsy (EML). Their safety was compared by measuring the incidences of post-ERCP pancreatitis (PEP) and other adverse events.

resultsA total of 350 patients were enrolled. Eligible patients were randomly assigned to the EST group (n = 116), EPBD group (n = 118), and ESBD group (n = 116). Sex, median age, number, and median size of small CBDSs were comparable. The first-session (all > 97%) and overall success rates of stone removal (all 100%) were high. No significant difference was detected in the incidence of EML (all < 1%). The incidences of PEP (all < 6%), bleeding, perforation, infection, and hyperamylasemia were low in all three groups, with no significant among-group differences.

conclusionEST, EPBD, and ESBD all exhibit excellent efficacy and safety in the removal of small CBDSs. EPBD is recommended as the optimal method for removing small CBDSs due to its simple procedures, functional preservation of the sphincter of Oddi, and fewer long-term complications.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeCholedocholithiasisGallstonesSphincterotomy, EndoscopicAdultAgedChinaDilatationFemaleHumansLithotripsyMaleMiddle AgedPancreatitisPostoperative ComplicationsProspective StudiesEndoscopic papillary balloon dilatationEndoscopic sphincterotomyEndoscopic sphincterotomy plus balloon dilatationPost-ERCP pancreatitisSmall common bile duct stone

Identifiers

PMID41044282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.