Evidence map›Paper›PMID 41044233›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Entire corpus callosum and diffuse white matter involvement in acute Marchiafava-Bignami disease.

Jieqiang Xia, Qing Lin, Xue Ke

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jieqiang Xia *Department of Neurology, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu, Sichuan, 610200, China.ORCID http://orcid.org/0000-0002-4820-1333
Qing Lin *Department of Neurology, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu, Sichuan, 610200, China.
Xue KeDepartment of Neurology, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu, Sichuan, 610200, China. 472017366@qq.com.ORCID http://orcid.org/0009-0007-0776-3405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute Marchiafava-Bignami disease (MBD) can extend beyond the corpus callosum to diffuse hemispheric white matter, portending poor outcomes. We report a 57-year-old man with long-standing alcohol abuse who developed weakness and coma. Magnetic resonance imaging (MRI) revealed hyperintense, swollen lesions throughout the corpus callosum and extracallosal white matter on T2-weighted imaging (T2WI)/fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging(DWI), consistent with cytotoxic edema. Despite prompt high-dose thiamine and aggressive supportive care, he died within days. This case underscores the diagnostic value of DWI for early detection and prognostication in acute MBD, and highlights the importance of urgent brain MRI in comatose patients with a background of chronic alcohol abuse.

Indexed as

Corpus CallosumMarchiafava-Bignami DiseaseWhite MatterAlcoholismDiffusion Magnetic Resonance ImagingFatal OutcomeHumansMagnetic Resonance ImagingMaleMiddle AgedCorpus callosumDiffusion-weighted imagingExtracallosal white matterMarchiafava-Bignami diseaseThiamine

Identifiers

PMID41044233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.