Evidence map›Paper›PMID 41044228›Full record

ReviewPediatric research2026

Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities.

Abbot Laptook, Aisling A Garvey, Caroline Adams, Patricia Ellen Grant, Eleanor J Molloy, Floris Groenendaal, Lauren C Weeke, Manon Benders, Misun Hwang, Mohamed El-Dib and 8 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Abbot LaptookDepartment of Pediatrics, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Aisling A GarveyDepartment of Neonatology, Cork University Maternity Hospital, Cork, Ireland.
Caroline AdamsDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Patricia Ellen GrantDepartment of Radiology and Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Eleanor J MolloyDiscipline of Paediatrics, Trinity Translational Medicine Institute (TTMI) & Trinity Research in Childhood Centre (TRiCC), Trinity College Dublin, Ireland.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Lundlaan 6, Utrecht, The Netherlands.
Lauren C WeekeDepartment of Neonatology, Radboudumc, Nijmegen, the Netherlands.
Manon BendersDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Lundlaan 6, Utrecht, The Netherlands.
Misun HwangDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Mohamed El-DibDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nadia BadawiGrace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Nicola J RobertsonInstitute for Women's Health, University College London, WC1E 6HX, 74 Huntley Street, London, UK.
Raymand PangInstitute for Women's Health, University College London, WC1E 6HX, 74 Huntley Street, London, UK.
Sudhin ThayyilDepartment of Brain Sciences, Imperial College, London, UK.
Terrie InderCenter for Neonatal Research, Childrens Hospital of Orange County, California, University of California, Irvine, CA, USA.
Ted Carl Kejlberg AndeliusDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Kasper Jacobsen KyngDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark. kasper.kyng@clin.au.dk.
Neonatal MRI group; Brain, Development, and Imaging section of the European Society of Pediatric Research (ESPR)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal encephalopathy (NE) is a significant global health concern. It is a leading cause of long-term neurodevelopmental impairment, with hypoxic-ischaemic perinatal brain injury being the most common underlying contributor. Although therapeutic hypothermia has reduced mortality and improved outcomes for some affected infants, many survivors experience neurodevelopmental disability, including cerebral palsy and/or deficits in cognition, behaviour, and executive functioning. Early and accurate prognostication and identification of injury severity remain a challenge due to evolving clinical signs and multiple etiologies. Magnetic resonance imaging (MRI) is the gold standard for characterizing NE-related brain injury. Diffusion-weighted imaging (DWI) enables early detection of injury, and proton magnetic resonance spectroscopy (

Indexed as

Brain DiseasesMagnetic Resonance ImagingBiomarkersBrainDiffusion Magnetic Resonance ImagingHumansHypoxia-Ischemia, BrainInfant, NewbornMagnetic Resonance SpectroscopyNeurodevelopmentPrognosisBiomarkers

Identifiers

PMID41044228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.