Evidence map›Paper›PMID 41044118›Full record

ArticleScientific reports2025

Discovery of new pyridine 3-carboxylic acid-based pharmacophores as dual anti-inflammatory and anti-hyperglycemic agents.

K Ramakrishnan, Lenin Nachimuthu, Reshma Rajan, J Premkumar, Vallabh Mulay, S Meenakshi, Chandrakala A Narasimhulu, Pragney Deme, Sanjay Rajagopalan, Ramanathan Lalgudi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K RamakrishnanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Lenin NachimuthuDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Reshma RajanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
J PremkumarDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Vallabh MulayDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
S MeenakshiDepartment of English, School of Social Sciences and Languages, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Chandrakala A NarasimhuluDivision of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, University Of Central Florida, Orlando, USA.
Pragney DemeDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sanjay RajagopalanDepartment of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ramanathan LalgudiAries Science & Technology, Columbus, OH, USA.
Akella SivaramakrishnaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
S KarthikeyanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Rajagopal DesikanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India. rajagopal.desikan@vit.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel nicotinic acid derivatives were synthesized as potent anti-diabetic agents. The developed inhibitors were investigated for their pharmacological in vitro screening, such as anti-diabetic, anti-inflammation, and in silico analysis. It has good interactions with α-amylase protein, with a range of -7.18 to -5.55 kcal/mol. The inhibitors were synthesized by employing the Steglich-type reaction to couple alcohol and amine derivatives. These molecules were characterized using NMR, FT-IR, and Mass spectrometry techniques. Anti-hyperglycemic activity has been screened using α-amylase protein, and the half-maximal inhibition efficiency (IC

Indexed as

Anti-Inflammatory AgentsHypoglycemic AgentsPyridinesalpha-AmylasesAntioxidantsDrug DiscoveryErythrocytesHemolysisHumansMolecular Docking Simulationalpha-AmylasesAnti-Inflammatory AgentsAntioxidantsHypoglycemic AgentsPyridinesAnti-hyperglycemic activityAnti-inflammatoryAnti-oxidantNicotinic acidΑ-amylase

Identifiers

PMID41044118
PMCPMC12494831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.