Evidence map›Paper›PMID 41044086›Full record

ArticleNPJ Parkinson's disease2025

Capsaicin and nicotine alleviate MPTP induced olfactory dysfunction by suppressing cGAS/TBK1/STING and MAPK mediated neuroinflammation.

Jingjing Wei, Linhai Wang, Dingzhong Wang, Weiwei Chen, Lulu Guo, Mengqian Ren, Fangxin Guo, Sisi Ruan, Hangcui Hu, Yao Zheng and 7 more

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Jingjing WeiFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Linhai WangFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Dingzhong WangBeijing Life Science Academy (BLSA), Beijing, China.
Weiwei ChenSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
Lulu GuoBeijing Life Science Academy (BLSA), Beijing, China.
Mengqian RenFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Fangxin GuoSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
Sisi RuanFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Hangcui HuSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
Yao ZhengSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
Siqi NanFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Zhiwen XuSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
Yan LiFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Hang YuanFlavour Science Research Center, College of Chemistry, Zhengzhou University, Zhengzhou, China.
Jian MaoBeijing Life Science Academy (BLSA), Beijing, China. 20012188mj@163.com.
Yan XuSchool of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China. yxu@zzu.edu.cn.
Jianping XieBeijing Life Science Academy (BLSA), Beijing, China.

Funding

The China Postdoctoral Science Foundation 2023M733887The scientific project of Beijing Life Science Academy 2023000CC0140, 2023000CB0010, 2024301QPIA01This research was funded by the National Natural Science Foundation of China 82101506, 32272455, 32072344
6 · The paper itself

Abstract

Olfactory dysfunction serves as a potential early diagnostic biomarker for Parkinson's disease (PD), providing essential evidence for investigating PD pathogenesis and developing neuroprotective strategies. Capsaicin (CAP) and nicotine (Nic), pungent flavor compounds derived from Solanaceae plants, exhibit anti-inflammatory properties. Epidemiological studies indicate that higher levels of chili pepper consumption and smoking are inversely associated with PD risk. However, the mechanisms of CAP and Nic against PD-related olfactory dysfunction remain unclear. In this study, we observed that CAP and Nic ameliorated olfactory dysfunction in MPTP intranasal-treated PD mice and alleviated dopaminergic damage in key brain regions including the olfactory bulb, anterior olfactory nucleus, striatum and substantia nigra. Both compounds suppressed microglial activation in these regions, downregulated IL-6 expression, and upregulated TGF-β protein levels. Furthermore, our findings demonstrated that CAP and Nic could effectively mitigate MPTP-induced olfactory deficits by attenuating neuroinflammation mediated through the cGAS/TBK1/STING and MAPK signaling.

Identifiers

PMID41044086
PMCPMC12494779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.