ArticleNature communications2025
The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The temporal organization of memory and emotion is reciprocally coupled.bioRxiv : the preprint server for biology · 2026Article
- Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis.Cognition · 2026Article
- A Passage of Time Signal in the Human Brain.eNeuro · 2026Article
- Temporal Context Reinstatement Drives Episodic-Like Order Memory in Long-Context Language Models.Proceedings of machine learning research · 2026Article
- Neural Representation of Episodic Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Changes in task-evoked activity in the entorhinal cortex (EC) and hippocampus have been shown to track changes in temporal context at short and long timescales. However, whether spontaneous changes in EC and hippocampal neural signals-in the absence of task demands-likewise reflect the passage of time remains unknown. Here, we leveraged a dense-sampling study in which two individuals underwent daily resting-state fMRI for 30 days. Similarity in EC- and anterior hippocampal-whole-brain resting connectivity patterns was negatively correlated with the time interval between sessions, suggesting a spontaneous, slow-drifting neural signature of time. These changes could not be explained by other time-varying factors (including session-wise changes in mood, hormones, or motion). Hippocampal connectivity temporal drifts followed an anterior-to-posterior gradient, and anterolateral EC showed stronger temporal drift than posteromedial EC. Finally, posterior networks (including visual and default mode) primarily drove drifts in EC- and hippocampal-whole-brain connectivity over time. Collectively, these findings reveal a resting-state connectivity signature that reflects the passage of time in the absence of task demands and follows a functional gradient along the longitudinal axis of the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.