Evidence map›Paper›PMID 41044041›Full record

ArticleAnnals of clinical and translational neurology2026

Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia-It Is Not Too Late.

Kathrin Reetz, Stella A Lischewski, Jörg B Schulz, Maximilian Praster, Miguel Pishnamaz, FACROSS study group, Imis Dogan, Sandro Romanzetti, Ravi Dadsena, Kerstin Konrad and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-9730-9228
Stella A LischewskiDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0003-1165-9153
Jörg B SchulzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-8903-0593
Maximilian PrasterDepartment for Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Miguel PishnamazDepartment for Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.
FACROSS study group
Imis DoganDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Sandro RomanzettiDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0001-8519-1309
Ravi DadsenaDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0001-7387-0750
Kerstin KonradSection Child Neuropsychology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen, University Hospital, Aachen, Germany.
Thomas ClavelFunctional Microbiome Research Group, Institute of Medical Microbiology, RWTH University Hospital, Aachen, Germany.
Vera JankowskiInstitute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany.
Joachim JankowskiInstitute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany.
Oliver PabstInstitute of Molecular Medicine, RWTH Aachen University, Aachen, Germany.
Nikolaus MarxDepartment of Internal Medicine I, Cardiology, RWTH Aachen University, Aachen, Germany.
Julia MoellmannDepartment of Internal Medicine I, Cardiology, RWTH Aachen University, Aachen, Germany.
Malte JacobsenDepartment of Internal Medicine I, Cardiology, RWTH Aachen University, Aachen, Germany.
Katharina Marx-SchüttDepartment of Internal Medicine I, Cardiology, RWTH Aachen University, Aachen, Germany.
Juergen DukartInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), RResearch Centre Jülich, Jülich, Germany.
Simon EickhoffInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), RResearch Centre Jülich, Jülich, Germany.
Ralf-Dieter HilgersDepartment of Medical Statistics, RWTH Aachen University, Aachen, Germany.

Funding

Medizinische Fakultät, RWTH Aachen University OC2
6 · The paper itself

Abstract

Friedreich's ataxia is a multisystem disorder with scoliosis being the most common non-neurological manifestation. While scoliosis surgery is typically performed in adolescent, ambulatory patients, few data exist on surgical outcomes in patients with advanced disease. We present a 38-year-old woman with late-stage Friedreich's ataxia and pronounced thoracolumbar scoliosis (Cobb angle 48°) causing severe pain and limited sitting tolerance. After posterior corrective spondylodesis (T4-ilium), she reported marked improvements in pain, sitting tolerance, function, and quality of life in the SF-36 questionnaire. This case highlights the potential for substantial clinical and functional benefits from scoliosis surgery in patients with advanced Friedreich's ataxia.

Indexed as

Friedreich AtaxiaScoliosisSpinal FusionAdultFemaleHumansFriedreich ataxiaquality of lifescoliosissurgery

Identifiers

PMID41044041
PMCPMC12790157

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.