Evidence map›Paper›PMID 41043999›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.

Tommaso Volpi, Jean-Dominique Gallezot, Shannan Henry, Mark Dias, Nikkita Khattar, Takuya Toyonaga, Kathryn Fontaine, Tim Mulnix, Jiazhen Zhang, Liang Guo and 5 more

Abstract readValidation Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Attenuation Pre-Correction in Iterative PET Image Reconstruction: What is the Statistical Cost?IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  3. Review
  4. Lower Muscarinic MBiological psychiatry · 2026
    Article
  5. Article
  6. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  7. Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tommaso VolpiYale University, New Haven, Connecticut tommaso.volpi@yale.edu.
Jean-Dominique GallezotYale University, New Haven, Connecticut.
Shannan HenryYale University, New Haven, Connecticut.
Mark DiasYale University, New Haven, Connecticut.
Nikkita KhattarYale University, New Haven, Connecticut.
Takuya ToyonagaYale University, New Haven, Connecticut.
Kathryn FontaineYale University, New Haven, Connecticut.
Tim MulnixYale University, New Haven, Connecticut.
Jiazhen ZhangYale University, New Haven, Connecticut.
Liang GuoYale University, New Haven, Connecticut.
Paul GravelYale University, New Haven, Connecticut.
Rajiv RadhakrishnanYale University, New Haven, Connecticut.
Ansel T HillmerYale University, New Haven, Connecticut.
David MatuskeyYale University, New Haven, Connecticut.
Richard E CarsonYale University, New Haven, Connecticut.

Funding

NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of NeurochemistryU01EB029811 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LI, HONGDI · 2020 to 2024
$10.0M
NIBIB NIH HHS U01 EB029811
6 · The paper itself

Abstract

Image-derived input functions are noninvasive alternatives to arterial blood sampling for PET kinetic modeling, allowing one to measure the whole-blood time-activity curve (BTAC). However, partial-volume effects have limited the use of carotid arteries (CA) to generate image-derived BTACs (ID-BTAC) for brain PET. The NeuroEXPLORER is a next-generation scanner with unprecedented spatial resolution, possibly allowing better CA ID-BTAC extraction.

Indexed as

Carotid ArteriesImage Processing, Computer-AssistedPositron-Emission TomographyAdultAgedFemaleHumansMaleMiddle AgedTime Factorscarotidshigh-resolution brain PETID-BTACNeuroEXPLORER

Identifiers

PMID41043999
PMCPMC12676648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.