Evidence map›Paper›PMID 41043908›Full record

ArticleJACC. Case reports2025

Patent Foramen Ovale Closure in Neuroendocrine Prostate Cancer-Induced Hepatopulmonary Syndrome: Fruitful or Futile?

Zoee U D'Costa, Nida Qadir, Rushi V Parikh, Jamil A Aboulhosn, Angela Li, John Shen, Irene Riahi, Alison Xiaotang Du, Eric H Yang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zoee U D'CostaDepartment of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Electronic address: zdcosta@mednet.ucla.edu.
Nida QadirDivision of Pulmonary and Critical Care, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Rushi V ParikhDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Jamil A AboulhosnDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA; Division of Cardiology, Department of Medicine, Ahmanson/UCLA Adult Congenital Heart Center, University of California at Los Angeles, Los Angeles, California, USA.
Angela LiDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA; Division of Cardiology, Department of Medicine, Ahmanson/UCLA Adult Congenital Heart Center, University of California at Los Angeles, Los Angeles, California, USA.
John ShenDepartment of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA.
Irene RiahiDepartment of Pathology, University of California at Los Angeles, Los Angeles, California, USA.
Alison Xiaotang DuDepartment of Pathology, University of California at Los Angeles, Los Angeles, California, USA.
Eric H YangDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA; UCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatopulmonary syndrome (HPS) is a cause of hypoxemia secondary to advanced liver disease. Neuroendocrine prostate cancer (NEPC) is a rare but highly aggressive cancer with poor prognosis. CASE SUMMARY: This is a unique case of hypoxemia from HPS induced by NEPC, exacerbated by right-to-left shunting from a previously insignificant patent foramen ovale (PFO). PFO closure yielded brief resolution of symptoms, but without early confirmation of NEPC diagnosis, the patient ultimately died. DISCUSSION: There are few cases in the literature that discuss HPS secondary to malignancy and none to date about NEPC causing HPS. This case highlights the importance of early identification of NEPC, clinical diagnosis strategy, and discussion of intervention of PFO closure in cases of HPS.

Indexed as

congenital heart defectechocardiographyhypoxemia

Identifiers

PMID41043908
PMCPMC12540277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.