ArticleImmunity2025
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis.
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Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- Gut Microbiota-Derived Indole-3-Acetaldehyde Contributes to the Disease-Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ZBP1-mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- MOG-Peptide Synergizes With Rapamycin to Drive CD4Immunology · 2026Article
- Early Combined B-Cell Depletion and BTK Inhibition Reduced TLS-like Structures and Relapse in PLPInternational journal of molecular sciences · 2026Article
- The role of DAP12 in immune-related inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells.Frontiers in immunology · 2026Article
- From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation.Journal of immunology research · 2026Review
- The potential connection between inflammatory bowel disease and Alzheimer's disease: mechanistic insights and therapeutic implications.Frontiers in immunology · 2026Review
- Acid-Responsive Zeolitic Imidazolate Framework-8 Core-Shell Nanovesicles Loaded with Interleukin-2 Nanoplatforms Selectively Expand Regulatory T Cells to Reconstruct Immunometabolic Homeostasis in Diabetic Neuropathy.Biomaterials research · 2026Article
- Gut microbiota-neuroimmune crosstalk in autoimmune encephalitis: mechanistic insights and therapeutic prospects.Frontiers in microbiology · 2026Review
- Modulatory effects of traditional Chinese medicine and derived active metabolites on autoimmune-inflammatory signaling pathways in multiple sclerosis: a narrative review.Frontiers in pharmacology · 2026Review
- Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
23 authors.
Mehdi BenamarDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Paola ContiniUnit of Clinical Immunology and Translational Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Internal Medicine (DIMI)-University of Genoa, Genoa, Italy.
Klaus Schmitz-AbeDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Division of Neonatology, Department of Pediatrics, University of Miami, Miami, FL, USA.
Olga LanzettaDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Feven GetachewDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Corinne BachelinSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, CIC Neurosciences, Paris, France.
Juan Manuel Leyva CastilloDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Muyun WangDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Fatma Betul OktelikDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye.
Océane PerrotSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, CIC Neurosciences, Paris, France.
Yvann BatamackDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Sena Nur ArbagDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Emmanuel Stephen-VictorDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Division of Microbiology and Immunology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
Hani HarbDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Insititute for Medical Microbiology and Virology, University Hospital Dresden, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Pankaj B AgrawalDivision of Neonatology, Department of Pediatrics, University of Miami, Miami, FL, USA.
Céline LouapreSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, CIC Neurosciences, Paris, France.
Federico IvaldiDepartment of Internal Medicine (DIMI)-University of Genoa, Genoa, Italy.
Antonio UccelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child University of Genova, Largo Daneo 3, Genova, Italy; Department of Neurology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Matilde IngleseDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child University of Genova, Largo Daneo 3, Genova, Italy; Department of Neurology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Claudia AngeliniIstituto per le Applicazioni del Calcolo "M. Picone", Consiglio Nazionale delle Ricerche, Napoli, Italy.
Violetta ZujovicSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, CIC Neurosciences, Paris, France.
Raffaele De PalmaUnit of Clinical Immunology and Translational Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Internal Medicine (DIMI)-University of Genoa, Genoa, Italy; CNR-Institute of Biomolecular Chemistry (IBC), Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy.
Talal A ChatilaDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: talal.chatila@childrens.harvard.edu.
Funding
Molecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9MControl of regulatory T cell homeostasis and function by Notch signalingR01AI115699 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE · 2017 to 2021
$2.2MNIAID NIH HHS R01 AI065617NIAID NIH HHS R01 AI115699
Abstract
The immune regulatory defects that promote neuroinflammation in multiple sclerosis (MS) remain unclear. We show that a specific regulatory T (Treg) cell subpopulation expressing Notch3 was increased in individuals with MS and in mice with experimental autoimmune encephalomyelitis (EAE). Notch3
Indexed as
Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisNeuroinflammatory DiseasesReceptor, Notch3T-Lymphocytes, RegulatoryAnimalsAutoimmunityCentral Nervous SystemFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaReceptor, Notch3central nervous systemDLL1EAEex-Treg cellsHippo pathwayimmune tolerancemultiple sclerosisNotch3NPY1Rregulatory T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.