ArticleMolecular cell2025
Targeted citrullination enables p53 binding to non-canonical sites.
Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Decoding isozyme-specific substrate recognition in protein arginine deiminases by in vitro lysate-based citrullination mapping.Nature communications · 2026Article
- The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy.bioRxiv : the preprint server for biology · 2026Article
- The Chromaverse Is Colored by Triplexes Formed Through the Interactions of Noncoding RNAs with HNPRNPU, TP53, AGO, REL Proteins, Intrinsically-Disordered Regions, and Flipons.International journal of molecular sciences · 2026Article
- Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms.MedComm · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
TP53 encodes for the transcription factor p53, which binds to a diverse set of target genes in response to stress. Activation of p53 results in highly specific transcriptional responses, but the regulation of promoter selectivity by p53 is poorly understood. Here, we report that sequence-specific binding of p53 is regulated by its target gene and binding partner peptidyl-arginine deiminase 4 (PADI4). PADI4 enzymatically converts peptidyl-arginine to peptidyl citrulline in a process known as citrullination. We show that PADI4 citrullinates p53 at the C terminus in vitro, and we confirm two citrullination events in cells and mouse tissue (R306 and R363). Chromatin immunoprecipitation sequencing (ChIP-seq) reveals that PADI4 expression causes a redirection of p53 away from a subset of canonical binding sites to target genes associated with ETS transcription factors. Chromatin profiling using citrullination-specific p53 antibodies supports this conclusion. These findings link citrullination to p53 function and illustrate how chromatin modifiers like PADI4 can direct the p53 transcriptional response.
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Registered trials
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