Evidence map›Paper›PMID 41043329›Full record

ArticleBioorganic chemistry2025

Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells.

Nursyuhada Azzman, Muhammad Shoaib Ali Gill, Nurshariza Abdullah, Denisse A Gutierrez, Armando Varela-Ramirez, Laura A Sanchez-Michael, Jose A Lopez-Saenz, Mohamad Nurul Azmi Mohamad Taib, Syed Adnan Ali Shah, Renato J Aguilera and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nursyuhada AzzmanSchool of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia; Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Pulau Pinang Kampus Bertam, Kepala Batas 13200, Pulau Pinang, Malaysia.
Muhammad Shoaib Ali GillInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Nurshariza AbdullahJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.
Denisse A GutierrezCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, United States of America.
Armando Varela-RamirezCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, United States of America.
Laura A Sanchez-MichaelCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, United States of America.
Jose A Lopez-SaenzCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, United States of America.
Mohamad Nurul Azmi Mohamad TaibNatural Products and Synthesis Organic Laboratory (NPSO Lab), School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia; Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
Renato J AguileraCellular Characterization and Biorepository Core Facility, Border Biomedical Research Center, Department of Biological Sciences, College of Science, The University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968-0519, United States of America.
Nafees AhemadSchool of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia. Electronic address: nafees.ahemad@monash.edu.

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Marc B Cox · 2019 to 2026
$35.1M
G-RISE at the University of Texas at El PasoT32GM144919 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2022 to 2024
$1.5M
Characterization of novel pyrazole compounds with potent anti-cancer activityR16GM149379 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI RENATO J AGUILERA · 2023 to 2026
$605k
NIGMS NIH HHS R16 GM149379NIGMS NIH HHS T32 GM144919NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

Quinolones are a class of compounds that have shown promising potential as anticancer agents. However, the current quinolones in clinical trials are currently hampered by their efficacy issues. Therefore, we designed and synthesized novel 4-quinolone-3-carboxamide derivatives 14-67. All the synthesized compounds were initially screened for their cytotoxicity activity using the MTT assay method and evaluated for their anticancer activities against leukemia and breast cancer cells using the Differential Nuclear Staining (DNS) assay. Six screened compounds exhibited low CC

Indexed as

4-QuinolonesAntineoplastic AgentsApoptosisTriple Negative Breast NeoplasmsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansMolecular StructureStructure-Activity Relationship4-QuinolonesAntineoplastic AgentsAnticancer agentsAntitumor agentsApoptosisCytotoxic activityQuinolones

Identifiers

PMID41043329
PMCPMC12677246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.