Evidence map›Paper›PMID 41043268›Full record

ArticleTalanta2026

Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method.

Sandra Adámez-Rodríguez, Eric D Queathem, Abdirahman Hayir, María Luisa Marina, María Castro-Puyana, Patrycja Puchalska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Talanta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra Adámez-RodríguezDepartment of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Ctra. Madrid-Barcelona, km. 33.600, Alcalá de Henares, E-28871, Madrid, Spain.
Eric D QueathemDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA; Division of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Abdirahman HayirDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
María Luisa MarinaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Ctra. Madrid-Barcelona, km. 33.600, Alcalá de Henares, E-28871, Madrid, Spain.
María Castro-PuyanaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Ctra. Madrid-Barcelona, km. 33.600, Alcalá de Henares, E-28871, Madrid, Spain.
Patrycja PuchalskaDivision of Molecular Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: ppuchals@umn.edu.

Funding

KETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2M
Minnesota Postbaccalaureate Research Education Program in Diabetes, Endocrinology and Metabolic DiseasesR25DK140753 · NIDDK · UNIVERSITY OF MINNESOTA · PI Emilyn Alejandro, LISA Senye CHOW · 2024 to 2026
$1.8M
Inclusive Excellence Training Program in the Systems Biology of Cardiovascular InflammationT32HL166142 · NHLBI · UNIVERSITY OF MINNESOTA · PI JOSEPH Mark METZGER · 2023 to 2026
$817k
NHLBI NIH HHS T32 HL166142NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R25 DK140753
6 · The paper itself

Abstract

Acetoacetate (AcAc) and β-hydroxybutyrate (βOHB) are ketone bodies involved in energy metabolism, particularly during physiological states of glucose scarcity, such as fasting, exercise, and the implementation of a ketogenic diet. The production (ketogenesis) and utilization (ketolysis) of ketone bodies are dynamic processes that can be quantified using stable isotope-labeled tracers in metabolic tracing studies, necessitating precise and sensitive analytical methods for accurately measuring both labeled and unlabeled pools. Although UHPLC-MS/MS has recently emerged as a reliable tool for quantifying ketone bodies, its dependence on

Indexed as

3-Hydroxybutyric AcidAcetoacetatesKetone BodiesTandem Mass SpectrometryCarbon IsotopesChromatography, High Pressure LiquidHumansIsotope Labeling3-Hydroxybutyric AcidAcetoacetatesacetoacetic acidCarbon IsotopesKetone BodiesAcetoacetateBeta-hydroxybutyrateFlux modelingKetone bodiesQuantificationStable isotopes

Identifiers

PMID41043268
PMCPMC12704222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.