Evidence map›Paper›PMID 41043050›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

All-Aqueous Phase Segregation Integrated Electrochemical Aptamer Biosensor Enables Picomolar Detection of SARS-CoV-2 Spike Protein.

Ryan Ho-Ping Siu, Yage Zhang, Sihan Liu, Andrew Brian Kinghorn, Wei Guo, Ho Cheung Shum, Julian Alexander Tanner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan Ho-Ping SiuSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.
Yage ZhangGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518060, China.
Sihan LiuDepartment of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, 999077, China.
Andrew Brian KinghornSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.
Wei GuoGuangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518060, China.ORCID 0000-0002-4018-986X
Ho Cheung ShumAdvanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong SAR, 999077, China.
Julian Alexander TannerSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.

Funding

Collaborative Research Fund C7165-20GFDevelopment and Reform Commission of Shenzhen Municipality Support Plan for Strategic Emerging Industries XMHT20240115002General Research Fund 17306221General Research Fund 17317322Government of the Hong Kong Special Administrative Region SST/118/20GPGuangdong Basic and Applied Basic Research Foundation 2024A1515010990National Natural Science Foundation of China 22302128Research Grants Council (RGC) of Hong KongRGC Senior Research Fellow SRFS2425-7S04Shenzhen Science and Technology Program RCBS20231211090713027Translational Seed Funding Grants
6 · The paper itself

Abstract

Electrochemical aptamer biosensors (E-ABs) are promising tools for rapid point-of-care (POC) diagnosis which utilize aptamers for the molecular recognition of specific disease biomarkers. However, E-AB sensitivity is typically limited by the binding affinity (K

Indexed as

Aptamers, NucleotideBiosensing TechniquesCOVID-19Electrochemical TechniquesSARS-CoV-2Spike Glycoprotein, CoronavirusHumansLimit of DetectionAptamers, NucleotideSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2aptamerelectrochemical biosensorliquid‐liquid phase separationSARS‐CoV‐2 spike protein

Identifiers

PMID41043050
PMCPMC12614154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.