Evidence map›Paper›PMID 41043004›Full record

ArticleJournal of Parkinson's disease2025

Parkinson's disease participant-led research: Towards neuroimaging-assisted deep brain stimulation programming.

Mark D McAuley, Alena A Ionova, Andreas Horn, Ethan Heming, Celestina A Onabajo, Madison M Solie, Sara A Stephenson, Susan E Boehnke

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark D McAuleySchool of Health Sciences, Swinburne University of Technology, Melbourne, Australia Email: markmcauley@swin.edu.au.ORCID 0009-0009-0034-2442
Alena A IonovaCentre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0009-0006-4404-2706
Andreas HornInstitute for Network Stimulation, Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-0695-6025
Ethan HemingORCID 0000-0002-0303-3065
Celestina A OnabajoCentre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0009-0007-9875-9937
Madison M SolieNipissing University, North Bay, Canada.ORCID 0009-0007-3243-0389
Sara A StephensonORCID 0009-0003-1274-8745
Susan E BoehnkeCentre for Neuroscience Studies, Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-0726-6659

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Deep brain stimulation (DBS) can improve Parkinson's disease symptoms; however, its effectiveness depends on selecting optimal settings. DBS parameter selection can be challenging, as objective metrics to guide the process are lacking. This n-of-1 study explored using functional near-infrared spectroscopy (fNIRS) to guide DBS programming. Led by the participant, the study embedded a patient perspective at the center of the project. Multiple DBS settings were tested, and their effects on gait and cortical functional connectivity were measured. The DBS program that best supported gait had the lowest functional connectivity with the left dorsolateral prefrontal cortex as seed. This suggests fNIRS may be used to guide individual optimization of DBS treatment.

Indexed as

Deep Brain StimulationDorsolateral Prefrontal CortexFunctional NeuroimagingParkinson DiseaseAgedFemaleHumansMaleMiddle AgedSpectroscopy, Near-InfraredDBS settings for gaitdeep brain stimulationparkinson's disease

Identifiers

PMID41043004
PMCPMC13347547

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.