Evidence map›Paper›PMID 41042948›Full record

ArticleNano letters2025

Photoacoustic Chemical Imaging of Tumor Microenvironment pH for Prediction of Chemotherapeutic Efficacy in Breast Cancer.

Jeff Folz, Janggun Jo, Ahmad Eido, Maria E Gonzalez, Roberta Caruso, Celina G Kleer, Xueding Wang

Abstract read
In one paragraph

Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Two-step distance tuning of TMaterials today. Bio · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeff FolzDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-4823-3343
Janggun JoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8131-7197
Ahmad EidoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-9530-2519
Maria E GonzalezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
Roberta CarusoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-9891-0082
Celina G KleerDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8195-185X
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-2974-6258

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Physiology of Inflammatory Arthritis in High ResolutionR01AR060350 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, XUEDING · 2011 to 2021
$6.0M
Role of EZH2 in Breast Cancer ProgressionR01CA107469 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Celina G Kleer · 2005 to 2026
$5.9M
Role of CCN6 (WISP3) in the Progression and Metastasis of Breast Cancer.R01CA125577 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Celina G Kleer · 2008 to 2026
$5.5M
Personalized Cancer Therapy Guided by Photoacoustic Chemical Imaging (PACI) of Tumor Microenvironment (TME)R01CA250499 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLEER, CELINA G, WANG, XUEDING · 2020 to 2025
$3.1M
Clinical Translation of dual-modality transrectal ultrasound and photoacoustic imaging for detection of aggressive human prostate cancerR01CA278833 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI Sri Rajasekhar Kothapalli, XUEDING WANG · 2023 to 2026
$1.8M
Detecting prostate cancer aggressiveness using photoacoustic chemical imaging with photoacoustic spectral analysisR01CA292946 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Janggun Jo · 2025 to 2026
$1.2M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA107469NCI NIH HHS R01 CA125577NCI NIH HHS R01 CA250499NCI NIH HHS R01 CA278833NCI NIH HHS R01 CA292946NIAMS NIH HHS R01 AR060350
6 · The paper itself

Abstract

An acidic microenvironment is a hallmark of solid tumors, which occurs due to cancer cells' preferential utilization of aerobic glycolysis. Both

Indexed as

Breast NeoplasmsPaclitaxelPhotoacoustic TechniquesTumor MicroenvironmentAnimalsAntineoplastic AgentsCell Line, TumorFemaleHumansHydrogen-Ion ConcentrationMiceNanoparticlesAntineoplastic AgentsPaclitaxelacidosisbreast cancerchemotherapynanoparticlesphotoacoustictumor microenvironment

Identifiers

PMID41042948
PMCPMC12836281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.