Evidence map›Paper›PMID 41042907›Full record

ArticleJournal of Parkinson's disease2025

A longitudinal study on physical activity in early Parkinson's disease.

Samuel Yong-Ern Ng, Darakhshan Naheed, Ehsan Seyed Saffari, Nicole Shuang-Yu Chia, Xinyi Choi, Dede Liana Heng, Shermyn Xiu-Min Neo, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au and 2 more

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samuel Yong-Ern NgDepartment of Research, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0002-0173-4925
Darakhshan NaheedDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Ehsan Seyed SaffariCentre for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6473-4375
Nicole Shuang-Yu ChiaDepartment of Research, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0002-5330-5014
Xinyi ChoiDepartment of Research, National Neuroscience Institute, Singapore, Singapore.
Dede Liana HengDepartment of Research, National Neuroscience Institute, Singapore, Singapore.ORCID 0009-0007-2188-4705
Shermyn Xiu-Min NeoDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Zheyu XuDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0002-7404-9240
Kay-Yaw TayDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Wing-Lok AuDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0002-1572-7259
Eng-King TanDepartment of Research, National Neuroscience Institute, Singapore, Singapore.
Louis Chew-Seng TanDepartment of Research, National Neuroscience Institute, Singapore, Singapore.ORCID 0000-0002-8415-401X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity (PA) remains critical in the slowing of disease progression in early Parkinson's disease (PD), although the longitudinal follow-up of such studies remain scarce. Using data from an early PD Cohort, we longitudinally examined the impact of unprescribed PA on symptoms of early PD, controlling for demographics and medications. Over five years, the reported PA in early PD declined significantly annually. When maintained, the overall PA had significant association with improved motor symptoms, cognition, and quality of life

Indexed as

Disease ProgressionExerciseParkinson DiseaseQuality of LifeAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedexerciseParkinson's diseasephysical activitysymptoms

Identifiers

PMID41042907
PMCPMC13347540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.