ArticleScience advances2025
Abnormal O-glycan sialylation in the mPFC contributes to depressive-like behaviors in male mice.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Disrupted O-GalNAc glycosylation as a mechanism and biomarker ofbioRxiv : the preprint server for biology · 2026Article
- Roles of NRXN1 in neuropsychiatric disorders: from genetic lesion to molecular mechanism.Frontiers in neuroscience · 2026Review
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Authors and funding
12 authors.
Funding
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Abstract
Depression presents challenges in understanding its biological basis and developing effective treatments. Posttranslational modifications provide critical insights into molecular mechanisms of disorders, yet their role in depression remains underexplored. Glycosylation has been particularly difficult to study due to its heterogeneous nature and analytical challenges, despite its potential to uncover previously unknown mechanisms. In this study, we demonstrate how chronic stress alters region-specific O-glycosylation across multiple brain regions, with a particular focus on the prefrontal cortex (PFC). Our findings reveal significant changes in sialylated O-glycosylation patterns mediated by
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