Evidence map›Paper›PMID 41042865›Full record

ArticleScience advances2025

Chromosome architecture affects virulence and competitiveness in

Ephraim Aliu, Keunsub Lee, Ram Sanath-Kumar, Christopher Youngstrom, Lander Geadelmann, Dibyajyoti Pramanik, Qing Ji, Xindan Wang, Kan Wang

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Genome Evolution in Plant Pathogenic Bacteria.Genome biology and evolution · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ephraim AliuDepartment of Agronomy, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-8173-2849
Keunsub LeeDepartment of Agronomy, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-3174-2475
Ram Sanath-KumarDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0009-0004-5793-2498
Christopher YoungstromDepartment of Agronomy, Iowa State University, Ames, IA 50011, USA.
Lander GeadelmannInterdepartmental Plant Biology Major, Iowa State University, Ames, IA 50011, USA.
Dibyajyoti PramanikDepartment of Agronomy, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-7996-1124
Qing JiCrop Bioengineering Center, Iowa State University, Ames, IA 50011, USA.ORCID 0009-0000-8403-2090
Xindan WangDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0001-6458-180X
Kan WangDepartment of Agronomy, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0003-2474-5800

Funding

Physicochemical properties driving membraneless organelle assembly in bacteriaR01GM143182 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BITEEN, JULIE, MEYER, ANNE SARA · 2021 to 2024
$2.4M
Determining the molecular basis of gene silencing by MucR and defining its role in Brucella virulenceR01AI172822 · NIAID · EAST CAROLINA UNIVERSITY · PI ROY M ROOP · 2023 to 2026
$2.3M
How bacterial SMC complexes organize chromosomes (Equipment Supplement)R01GM141242 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WANG, XINDAN · 2021 to 2025
$1.8M
NIAID NIH HHS R01 AI172822NIGMS NIH HHS R01 GM141242NIGMS NIH HHS R01 GM143182
6 · The paper itself

Abstract

Chromosome architecture plays a crucial role in bacterial adaptation, yet its direct impact remains unclear. Different bacterial species and even strains within the same species exhibit diverse chromosomal configurations, including a single circular or linear chromosome, two circular chromosomes, or a circular-linear combination. To investigate how these architectures shape bacterial behavior, we generated near-isogenic strains representing each configuration in

Indexed as

Agrobacterium tumefaciensChromosomes, BacterialGene Expression Regulation, BacterialVirulence

Identifiers

PMID41042865
PMCPMC12494015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.