Evidence map›Paper›PMID 41042836›Full record

ArticleCNS oncology2025

Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma.

Kishore Balasubramanian, Kar-Ming Fung, Rene Y McNall-Knapp, Karl Balsara

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kishore BalasubramanianDepartment of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
Kar-Ming FungDepartment of Pathology, University of Oklahoma Health Sciences Center, USA.
Rene Y McNall-KnappDepartment of Pediatrics, Jimmy Everest Center Section of Pediatric Hematology Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Karl BalsaraDepartment of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 7-year-old female with recurrent midline pilocytic astrocytoma harboring a rare

Indexed as

Antineoplastic AgentsAstrocytomaBrain NeoplasmsProtein Kinase InhibitorsPyrazolesPyrimidinesReceptor, trkBChildFemaleHumansMembrane GlycoproteinsNeoplasm Recurrence, LocalOncogene Proteins, FusionAntineoplastic AgentslarotrectinibMembrane GlycoproteinsOncogene Proteins, FusionProtein Kinase InhibitorsPyrazolesPyrimidinesReceptor, trkBtropomyosin-related kinase-B, humanLarotrectinibmidline gliomaNTRK2 fusionpediatric gliomapilocytic astrocytomatargeted therapy

Identifiers

PMID41042836
PMCPMC12498535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.