Evidence map›Paper›PMID 41042787›Full record

ArticlePloS one2025

Incidence and prevalence of neurodevelopmental disorders and disabilities among métis children in Alberta, Canada: A retrospective birth cohort study.

Stuart Lau, Jesus Serrano-Lomelin, Matt Hicks, Reagan Bartel, Kelsey Bradburn, Ashton James, Susan Crawford, Jeffrey A Bakal, Amy Colquhoun, Anne Hicks and 5 more

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stuart LauDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.
Jesus Serrano-LomelinDepartment of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Matt HicksDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Reagan BartelOtipemisiwak Métis Government of the Métis Nation within Alberta, Edmonton, Alberta, Canada.
Kelsey BradburnOtipemisiwak Métis Government of the Métis Nation within Alberta, Edmonton, Alberta, Canada.
Ashton JamesOtipemisiwak Métis Government of the Métis Nation within Alberta, Edmonton, Alberta, Canada.
Susan CrawfordAlberta Health Services Provincial Research Data Services, Edmonton, Alberta, Canada.
Jeffrey A BakalAlberta Health Services Provincial Research Data Services, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-3658-2554
Amy ColquhounHealth Analytics, Alberta Health, Calgary, Alberta, Canada.
Anne HicksDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Manoj KumarDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Rhonda J RosychukDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0001-8019-5466
Alvaro Osornio-VargasDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0001-8287-7102
Radha ChariDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.
Maria B OspinaDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0001-9305-7521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited research has examined the neurodevelopmental health of Métis children from a functional perspective, which is essential for culturally sensitive service planning, and policy development. This population-based retrospective birth cohort study linked provincial administrative health data of Métis and non-Métis singleton live births (2006-2016) to follow them up to 10 years of age. A random 1:4 sample of non-Métis children served as a reference group. Neurodevelopmental disorders and disabilities (NDD/D) were examined across six functional NDD/D domains. Prevalence odds ratios (pOR) with 95% confidence intervals (CI) were calculated using logistic regression models, adjusted for maternal and neonatal characteristics. Incidence rates (IR) per 1,000 person-years were estimated, and age-specific IR was modeled using longitudinal Poisson regression, adjusting for covariates. Associations between maternal and neonatal characteristics and NDD/D incidence among Métis children were examined using multivariable longitudinal Poisson regression models, with adjusted incidence rate ratios (IRR) and 95% CI reported. A total of 38,958 singleton live births were included (7,853 Métis and 31,105 non-Métis). Overall NDD/D prevalence among Métis (3.3%) and non-Métis (2.8%) children did not differ significantly after adjustment (adjusted pOR: 1.1, 95% CI: 0.9, 1.3). Learning-cognition was the most prevalent NDD/D domain. Métis children had a higher IR of NDD/D at age 2 (5.5 vs. 2.8 cases per 1,000 person-years, rate difference: 2.7 [95% CI: 0.8, 4.6]). Among Métis children, higher NDD/D incidence was associated with maternal age younger than 20 or older than 35 years, high pre-pregnancy weight, male sex, preterm birth, and congenital anomalies. While overall NDD/D prevalence was similar between Métis and non-Métis children, Métis children were more likely to be diagnosed at age 2, suggesting potential differences in early diagnosis, access to care, or underlying risk factors. A functional classification approach of neurodevelopmental health supports culturally responsive early screening and intervention strategies to address these differences.

Indexed as

Neurodevelopmental DisordersAdultAlbertaBirth CohortChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMalePrevalenceRetrospective StudiesYoung Adult

Identifiers

PMID41042787
PMCPMC12494283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.