ArticlePloS one2025
Environmental enrichment as a therapeutic strategy against methamphetamine induces depressive behaviors in mice.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Cognitive effects of methamphetamine and amphetamine withdrawal in rodents: a systematic review.Frontiers in psychology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methamphetamine (METH) abuse is associated with addiction, emotional dysregulation, motor impairments, cognitive deficits, and depressive symptoms, which are exacerbated by stress and social isolation. This study investigated the therapeutic potential of combined treatment and environmental enrichment in METH withdrawn mice. Behavioral, biochemical and neurochemical outcomes were evaluated. Post-treatment results demonstrated: motor and exploratory behavior via OFT (open field test) mobility increased to from 32.37 meters (withdrawal group) to 59.52 meters, anxiety reduction indicated in EPM (elevated plus maze test) open arm rose from 33.2 to 74.2 sec, while cognitive improvement by MWM (morris water maze test) escape latency decreased from 225.4 to 127.4 sec in hidden platform trial. Moreover, memory and exploration activity were determined by NOR (novel object recognition test) and HBT (hole board test) which showed enhanced novel object exploration (16.4 vs 5 sec) and exploratory behavior (17.6 explored areas vs 8.6). Social interaction time increased to 41.64 sec, and light-dark compartment preference improved to 68.4%. Biochemical analysis revealed elevated antioxidants enzymes activity POD (peroxidase) (0.178 U/min) SOD (superoxide dismutase) (0.82 U/mg protein) and CAT (catalase) (3.6 U/min) indicating improved oxidative stress resilience. Neurotransmitters restoration was observed with serotonin (0.21 µg/mg) and dopamine (0.46 µg/mg) levels rebounding from negligible withdrawn group. These findings demonstrate that combined treatment and enriched environment robustly accelerate functional recovery in METH-withdrawn mice, suggesting a promising strategy for mitigating addiction-related deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.