ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025
Assessment of insulin resistance in different phases of bipolar disorder with the triglyceride glucose index, triglyceride glucose-body mass index, and metabolic score index for insulin resistance.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo determine whether there are differences in the parameters triglyceride glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), and metabolic score index for insulin resistance (METS-IR) between subgroups of patients diagnosed with bipolar disorder (BD) - in euthymic, manic, and depressive states - and healthy controls.
methodsA total of 238 patients diagnosed with BD and 90 healthy controls were included in the study.
resultsTyG-BMI was higher in depressed-state BD patients than in manic-state BD patients. The METS-IR was significantly higher in depressed BD patients than in healthy controls. TyG-BMI was a statistically significant predictor of euthymic and depressed states of BD. In addition, the METS-IR was a statistically significant predictor of euthymic-state BD, depressed-state BD, and BD overall. In the receiver operating characteristic (ROC) analysis, we obtained the highest area under the ROC curve (AUC) values in the parameters TyG-BMI and METS-IR to discriminate the patient groups from healthy controls.
conclusionThis is the first study to provide evidence that elevated levels of METS-IR and TyG-BMI may be an indicator of IR in BD patients and can be used to differentiate BD patients from healthy controls. However, there is a need for confirmation of these results in larger studies before definitive conclusions can be drawn.
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