ArticleCell reports2025
Tension transmission across a supracellular network drives increased tissue rigidity in the Drosophila retina.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cell and tissue mechanics in 3-D organ morphogenesis: Insights from Drosophila pupal retina development.Developmental biology · 2026Review
- A natural programmable metamaterial controls 3D curvature of compound eyes.Nature communications · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Organ morphologies generated in development must be maintained in dynamic growth environments over long physical distances and timescales. How complex tissues like the Drosophila retina execute specialized cellular morphogenetic programs while maintaining their larger, tissue-scale morphology is not well understood. Here, we show that the developing retina acquires an organ scale curvature early in pupal development. Concurrently, uniform, sustained Rok-mediated actomyosin contractility organized through apical cellular adhesions in interommatidial pigment cells (IOPCs) increases junctional tension across the ommatidial network to drive a ∼5-fold increase in tissue rigidity. Induction of mosaic defects in IOPC junctional tension coupled with in silico modeling of the IOPC network revealed that tension transmission within the IOPC network bridges the cell and tissue scales, providing structural integrity to the retina without changing ommatidial geometry. We propose that tension transmission across tissue-spanning supracellular networks, by uniformly modulating epithelial rigidity, can stabilize three-dimensional organ morphology.
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