In one paragraphArticle in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Mireia García-LópezLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-9643-7172 Sabela LensLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0003-4900-411X Laura J PallettDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0002-4161-9462 Anna PocurullLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-1970-1822 Thais LeonelLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0003-2919-5676 Ernest BelmonteRadiology Department, Centro de Diagnóstico Por la Imagen (CDI), Hospital Clínic, University of Barcelona, Barcelona, Spain.ORCID 0000-0003-3572-9769 Ester García-PrasLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-2920-2306 Sergio Rodríguez-TajesLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-3189-7557 Zoe MariñoLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0001-6321-9534 Maria Sàez-PalmaLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0009-0000-2504-9677 Concepción BartresLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.
Ariadna Rando-SeguraLiver Pathology Unit, Department of Biochemistry and Microbiology, Hospital Universitari Vall D'hebron, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.ORCID 0000-0003-4555-7286 Francisco Rodríguez-FríasLiver Pathology Unit, Department of Biochemistry and Microbiology, Hospital Universitari Vall D'hebron, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.ORCID 0000-0002-9128-7013 Jonah LinToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Adam J GehringToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-1150-5840 Mala K MainiDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0001-6384-1462 Xavier FornsLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-8188-1764 Sofía Pérez-Del-PulgarLiver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.ORCID 0000-0002-9890-300X Funding
Asociación Española para el Estudio del HígadoEuropean Commission 848223Generalitat de Catalunya 2021_SGR_01322Instituto de Salud Carlos III FI23/00089Instituto de Salud Carlos III IFI18/00006Instituto de Salud Carlos III MV21/00003Instituto de Salud Carlos III PI18/01436Instituto de Salud Carlos III PI19/00036Instituto de Salud Carlos III PI20/00609Instituto de Salud Carlos III PI22/00013Societat Catalana de DigestologiaWellcome TrustWellcome Trust 214191/Z/18/Z
6 · The paper itselfAbstract
BACKGROUND AND
aimPD-1-expressing T cells within the HBV-infected liver constitute a target of novel immunotherapeutics. Our aim was to investigate the impact of viral suppression on PD-1 expression on intrahepatic versus circulating lymphocyte populations from chronic hepatitis B (CHB) patients.
methodsTwenty-two CHB patients, nine of them on nucleos(t)ide analogues (NUCs), had paired blood, liver fine needle aspirations (FNAs) and biopsies. A subset had a follow-up FNA after treatment initiation (n = 4) or discontinuation (n = 4). Intrahepatic (iHBV-DNA and cccDNA) and serum (HBV-DNA, HBsAg, HBcrAg and cirB-RNA) viral markers were quantified. Flow cytometry was used for immunophenotyping PBMCs and intrahepatic lymphocytes. An independent liver FNA scRNAseq dataset was used to consolidate our results.
resultsPD-1 expression on tissue-resident memory CD8 T cells (T
conclusionsIntrahepatic viral markers correlate with PD-1 expression on global liver-resident T cells of CHB patients with mild hepatitis, with a reduction after prolonged NUC therapy and re-expression following treatment withdrawal.
Indexed as
Antiviral AgentsCD8-Positive T-LymphocytesHepatitis B, ChronicHepatitis B virusNucleosidesProgrammed Cell Death 1 ReceptorAdultDNA, CircularDNA, ViralFemaleHumansLiverMaleMiddle AgedViral LoadAntiviral AgentsDNA, CircularDNA, ViralNucleosidesPDCD1 protein, humanProgrammed Cell Death 1 Receptorantiviral therapycovalently closed circular DNAhepatitis B virusimmune responsePD‐1viral biomarkers
Identifiers
PMID41042630
PMCPMC7619358
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