Evidence map›Paper›PMID 41042467›Full record

ArticleAnnals of surgical oncology2026

Decision Regret and Burden in Caregivers of Patients with Appendiceal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Alissa Greenbaum, Mikaela Kosich, Lauren Marek, Erin Ward, Shane Pankratz, Shiraz I Mishra, Vinay K Rai, Sarah Popek, Lara McKean Baste, Matthew C Hernandez and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alissa GreenbaumUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. AGreenbaum@salud.unm.edu.ORCID http://orcid.org/0000-0003-2523-2919
Mikaela KosichUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Lauren MarekDepartment of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Erin WardHuntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA.
Shane PankratzUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Shiraz I MishraUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Vinay K RaiUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Sarah PopekUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Lara McKean BasteUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Matthew C HernandezUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Bridget FahyUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInformal caregivers of patients with appendiceal cancer (AC) undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) may experience physical and psychological distress. The aim of this study was to determine the incidence of burden and decision regret among caregivers of patients with AC who underwent CRS-HIPEC. PATIENTS AND

methodsAn anonymous, IRB-exempt survey was administered to caregivers of patients with AC who underwent CRS-HIPEC. The primary outcome was caregiver burden (ZBI-12 survey). Secondary outcomes were assessed with the Decision Regret Scale (DRS), PROMIS-29 v 2.0 for quality of life (QOL), and the FACIT-COST for financial toxicity (FT).

resultsA total of 34 caregivers were included. The mean ZBI-12 score was 16 (IQR 9.5-22.5), which has been described as a meaningful cutoff for high burden. There were no major demographics or tumor characteristic differences between high and low burden groups. The most common burdens were feeling stressed caring for their family member (58.8%) and feeling they had lost control of their life since their relative's illness (26.5%). Caregiver burden was significantly related to increased decision regret (R = 0.399, p = 0.019). Higher FT was seen in incomplete surgical debulking (58.3% in the high FT group versus 0%; p = 0.005) and patients and caregivers who traveled ≥ 50 miles to the CRS-HIPEC center.

conclusionsHalf of caregivers reported high burden, which was associated with worse QOL and regret. Future studies will explore opportunities to improve support and resources for caregivers of patients undergoing CRS-HIPEC, both perioperatively and in the long-term.

Indexed as

Appendiceal NeoplasmsCaregiversCost of IllnessCytoreduction Surgical ProceduresDecision MakingEmotionsHyperthermic Intraperitoneal ChemotherapyQuality of LifeAdultAgedCombined Modality TherapyFemaleFollow-Up StudiesHumansHyperthermia, InducedMaleAppendiceal cancerCaregiver burdenCytoreductive surgeryDecision regretHyperthermic intraperitoneal chemotherapyPseudomyxoma peritoneiQuality of life

Identifiers

PMID41042467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.