SynthesisMolecular biology reports2025
Molecular mechanisms of sex hormones in Hepatocellular Carcinoma: a systematic review.
Synthesis in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Clinical and Genetic Determinants of Hepatocellular Carcinoma in a Turkish Cohort: Impact ofInternational journal of molecular sciences · 2026Article
- Age modulates estradiol's dual role in hepatocellular carcinoma recurrence after ablation: A prospective observational study.iScience · 2026Article
- Testosterone and Androgen Receptor in Cancers with Significant Sex Dimorphism in Incidence Rates and Survival.Cancers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex hormones have a prominent role in the gender disparity that is apparent in hepatocellular carcinoma (HCC). This systematic review investigates the molecular mechanisms of sex hormones-androgens, estrogens, and testosterone-in HCC, addressing the gender disparities observed in HCC prevalence and progression. Relevant search terms were used to retrieve pertinent studies found in PubMed, Web of Science, and Scopus which investigated the molecular mechanism of sex hormones in developing HCC. A quality assessment using a tailored checklist was performed. This study is registered with PROSPERO (CRD42025635841). Out of the 3,076 retrieved articles, 34 met the inclusion criteria, with six focusing on androgens, fifteen on estrogens, and thirteen examining multiple sex hormones. Studies utilized in vitro and in vivo models to understand the complex interplay between sex hormones and HCC. Estrogens were found to exert protective effects through anti-inflammatory, anti-proliferative, and mitochondrial integrity mechanisms, while androgens promoted tumorigenesis via cell cycle regulation and immune checkpoint modulation. The review highlights the contrasting roles of estrogens and androgens, emphasizing the necessity for a thorough understanding of their molecular interactions and signaling pathways, such as JAK-STAT, Wnt/β-catenin, and PI3K-AKT. This review underscores the potential for sex hormone pathway targeting in HCC therapy. Further research is warranted to explore therapeutic interventions, such as estrogen receptor antagonists and androgen receptor modulators, and to address gaps in understanding hormonal influences on HCC progression.
Indexed as
Identifiers
41042392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.