Observational studyLangenbeck's archives of surgery2025
Impact of acute pancreatitis on the outcomes of cholecystectomy. An observational multicenter retrospective study.
Observational study in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGallstones are the most common cause of acute pancreatitis (AP), which usually necessitate hospitalization. Although cholecystectomy is required to prevent recurrent episodes, no clear guidelines have been established yet regarding the proper timing of cholecystectomy after an AP incidence. The objective was to evaluate the impact of AP on the course of cholecystectomy procedures, both by comparing patients with and without a history of AP and by analyzing the AP subgroup according to timing and severity.
methodsThis retrospective evaluation was performed on patients who had undergone cholecystectomy for various causes in six hospitals in Poland. Patients were divided into the following three groups: patients without AP, patients with a history of AP, and patients with active AP. The analyzed variables included the surgical type and duration, postoperative complications, AP severity, and time elapsed between cholecystectomy and AP treatment completion.
resultsIn total, 4183 patients were included in the study, including 3948 without AP, 209 with a history of AP, and 26 with active AP. The most common surgical indications in patients with active AP and history of AP were concomitant cholecystitis (53.85%) and cholelithiasis (82.3%), respectively. The mean complication rates were not significantly different between groups. The surgical type was significantly affected by AP severity. Surgery in the period between 15 and 31 days post-AP attack was associated the highest frequency of minimally invasive surgery and shortest surgical duration, although the differences were not significant.
conclusionInflammation is the most common associated cause of surgery during the course of active AP. Surgery at 15-31 days post-AP attack was associated with a higher frequency of minimally invasive surgery and shorter operative duration, although these differences did not reach statistical significance. Our findings therefore suggest, but do not confirm, that this may represent a favorable time window, which warrants further evaluation in prospective studies.
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