Trial reportLangenbeck's archives of surgery2025
Efficacy of bupivacaine liposome transversus abdominis plane block in enhancing postoperative recovery following laparoscopic colorectal cancer resection.
Trial report in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Anterior Quadratus Lumborum Block with Liposomal Bupivacaine versus Ropivacaine for Postoperative Recovery in Laparoscopic Colorectal Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Optimizing transversus abdominis plane blocks in colorectal surgery: methodological queries and the fundamental question of indication.Langenbeck's archives of surgery · 2026Article
- Effects of oliceridine-based patient-controlled intravenous administration on postoperative pain and hemodynamic stability in elderly patients undergoing laparoscopic surgery for colorectal cancer.American journal of cancer research · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of bupivacaine liposome transversus abdominis plane (TAP) block on laparoscopic colorectal cancer resection patients for clinical practice.
methodsThis randomized controlled trial involved 60 patients (aged 57-84 years, weighing 41-84 kg, mean BMI 21.9 kg/m², ASA Class I/II) undergoing laparoscopic colorectal cancer resection with TAP block. Patients were divided into bupivacaine (Bup) and bupivacaine liposome (Bup + Lip) groups, each with 30 patients. Primary outcomes were postoperative visual analog scale (VAS) scores and sufentanil use. Secondary outcomes included recovery room stay, time to initiate oral intake, 72-h recovery quality, pain control satisfaction, and adverse event incidence.
resultsThe study included 28 patients in Bup group and 27 patients in Bup + Lip group in the modiffed intention-to-treat (mITT) population. Compared to the Bup group, the Bup + Lip group had significantly lower VAS scores for both rest and movement at 12, 24, 48, and 72 h postoperatively (P < 0.05), reduced total sufentanil use (P < 0.05), shorter time to initiate oral intake (P < 0.05), and improved 72-h recovery quality (P < 0.05) and pain control satisfaction (P < 0.05). The Bup + Lip group also had a significantly lower incidence of adverse events within 72 h postoperatively (P < 0.05).
conclusionBupivacaine liposome TAP block significantly improves postoperative pain control, reduces recovery time, and enhances recovery quality and patient satisfaction with low adverse event incidence in laparoscopic colorectal cancer resection patients. It is an effective postoperative analgesic strategy recommended for clinical application.
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