Evidence map›Paper›PMID 41042303›Full record

Trial reportPflugers Archiv : European journal of physiology2025

Intravascular volume expansion is prominently overestimated via hemoglobin concentration: a placebo-controlled and cross-over trial.

Meihan Guo, David Montero

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Meihan GuoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
David MonteroFaculty of Medicine, Hong Kong University, Hong Kong, Hong Kong SAR, China. dvmb@hku.hk.

Funding

Research Grant Council of Hong Kong 106210224
6 · The paper itself

Abstract

Blood volume (BV) expansion by means of intravenous infusion of colloids is an established procedure in clinical interventions. The essential questions of how much of the infused fluid stays in the circulation according to measured changes in hemoconcentration are uncertain. A placebo-controlled, single-blinded, and cross-over design was implemented to assess the effect of a definite increment in BV on hemodilution, as determined by hemoglobin concentration ([Hb]). Healthy women (n = 17) and men (n = 19) matched by sex, age (age = 26 ± 4 vs. 27 ± 3 yr, P = 0.522), and physical activity were subjected in a blind manner to the intravenous infusion of placebo-sham (PBO-sham) via saline infusion (10 mL; BD 0.9% NaCl) or albumin (volume equivalent to 10% of BV; Albumin CSL 20%). [Hb] was slightly reduced (-2.4%) after the PBO-sham infusion. For the albumin infusion, the amount of fluid infused ranged from 325 to 810 mL (547 ± 112 mL) in order to elicit a 10% increment in BV in each individual. [Hb] was markedly reduced (-17.2%) (13.8 ± 1.6 vs. 11.5 ± 1.4 g·dL

Indexed as

Blood VolumeHemoglobinsAdultAlbuminsCross-Over StudiesFemaleHemodilutionHumansInfusions, IntravenousMaleAlbuminsHemoglobinsAlbumin infusionCardiac filling pressureColloid infusionIntravascular expansionSex differences

Identifiers

PMID41042303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.