Evidence map›Paper›PMID 41042296›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2026

Human Stem Cell-Based Embryo Model Research: Ethics and Regulations.

Chie Kobayashi, Shu Ishida, Tsutomu Sawai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chie KobayashiUehiro Division for Applied Ethics, Graduate School of Humanities and Social Sciences, Hiroshima University, Higashihiroshima, Japan.
Shu IshidaUehiro Division for Applied Ethics, Graduate School of Humanities and Social Sciences, Hiroshima University, Higashihiroshima, Japan.
Tsutomu SawaiUehiro Division for Applied Ethics, Graduate School of Humanities and Social Sciences, Hiroshima University, Higashihiroshima, Japan. tstmsw@hiroshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given rapid advances in the life sciences, stem cell-based embryo models (SCBEMs) call for careful ethical and regulatory consideration. As with similar research related to human embryos and reproduction, SCBEMs raise important normative questions. In this chapter, we survey these questions, outline possible answers, and discuss their implications for global regulatory development. We also map major ethical issues related to SCBEM research, identify areas in need of further debate, and examine the governance frameworks required for responsible progress. We conclude with recommendations to guide SCBEM research so that it advances scientific innovation while protecting the public interest. In particular, we highlight the importance of careful planning, transparent communication, inclusive dialogue, robust governance, and ongoing empirical inquiry. Taken together, these measures can help ensure that SCBEM research proceeds responsibly, remains ethically sound, and earns public trust.

Indexed as

Embryo ResearchHuman Embryonic Stem CellsStem Cell ResearchHumansEmbryonic stem cellsHuman reproductionInduced pluripotent stem cellsInformed consentMoral StatusPublic trustResponsible scienceStem cell–based embryo modelsStem cell researchTechno-moral change

Identifiers

PMID41042296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.