Evidence map›Paper›PMID 41042256›Full record

ArticleEpilepsia2025

Hippocampal abnormality and response to vagus nerve stimulation in epilepsy.

Harry J Clifford, Sonja Fenske, Jonathan Horsley, Callum Simpson, Nathan Evans, Yujiang Wang, Tiago da Silva Costa, Rhys H Thomas, Sabahat Iqbal, Cameron A Elliott and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harry J CliffordCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Sonja FenskeCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Jonathan HorsleyCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Callum SimpsonCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Nathan EvansCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Yujiang WangCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-4847-6273
Tiago da Silva CostaFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Rhys H ThomasFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-2062-8623
Sabahat IqbalUCL Queen Square Institute of Neurology, London, UK.ORCID https://orcid.org/0000-0001-7658-6384
Cameron A ElliottDivision of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
John S DuncanUCL Queen Square Institute of Neurology, London, UK.
Peter N TaylorCNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-2144-9838

Funding

NIHR Newcastle Biomedical Research CentreUK Research and Innovation MR/T04294X/1UK Research and Innovation MR/V026569/1
6 · The paper itself

Abstract

Vagus nerve stimulation (VNS) reduces seizure frequency and severity in some, but not all, individuals with epilepsy. The hippocampus has been implicated in VNS response, but is yet to be studied structurally using T1-weighted (T1w) magnetic resonance imaging (MRI). In this study we hypothesized greater hippocampal abnormality in VNS non-responders. Using hippocampal morphometrics, we extracted the volumes of four hippocampal regions from T1w MRI across three groups; VNS responders (

Indexed as

EpilepsyHippocampusVagus Nerve StimulationAdolescentAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment OutcomeYoung AdultbiomarkerMRIprediction

Identifiers

PMID41042256
PMCPMC12779329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.