ReviewBiology of the cell2025
Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology.
Review in Biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mechanistic Pathways of Wound Healing: From Hemostasis to Scar-Free Regeneration.Cell biochemistry and function · 2026Review
- Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology.Biology of the cell · 2025Review
- Insights into lysosome-related organelle biogenesis: melanosome as a model organelle.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The endolysosomal system is a highly dynamic and versatile network of organelles essential for maintaining cellular and tissue homeostasis. Its functional diversity relies on a high degree of plasticity, driven by tightly regulated membrane remodeling and intracellular trafficking events. In certain specialized cells, this plasticity enables the formation of lysosome-related organelles, like melanosomes in pigment cells, through the repurposing of ubiquitous membrane trafficking machineries. Disruption of these pathways can lead to pathological conditions, including genetic disorders. In this review, we explore how endolysosomal plasticity underlies key adaptive cellular strategies at the cellular and tissue levels. Focusing on melanocytes, which synthesize melanin, and keratinocytes, which receive and store it, we illustrate how trafficking and membrane dynamics events coordinate between these two cell types for skin pigmentation and photoprotection, and how mutations affecting these processes lead to genetic forms of albinism. By using skin pigmentation as a model of cell- and tissue-specific adaptation, this review highlights the broader physiological and pathological implications of endolysosomal membrane morphodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.