ArticleBiology of the cell2025
Membrane Bound E-Cadherin Stimulates PI3K/Akt Signaling.
Article in Biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Estimation Model of Pig Weight Based on Body Measurements and Analysis of Its Genetic Basis.Animal genetics · 2026Article
- Membrane Bound E-Cadherin Stimulates PI3K/Akt Signaling.Biology of the cell · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cell junction proteins play a pivotal role in regulating key physiological processes, including proliferation and apoptosis. E-cadherin, a crucial component of adherens junctions, is essential for maintaining intestinal epithelial homeostasis by modulating cell adhesion and proliferation. In this study, we explored the function of E-cadherin in the intestinal epithelial cells. Our findings indicate that during colitis, E-cadherin remains associated with the cell membrane in colonocytes. Furthermore, using an in vitro system, we demonstrated that in colonocytes, E-cadherin inhibits cell proliferation and β-catenin signaling while simultaneously activating the PI3K/Akt pathway. These results suggest that E-cadherin may suppress cell proliferation while promoting PI3K/Akt signaling in colonocytes of colitic mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.