Evidence map›Paper›PMID 41042133›Full record

ArticleeLife2025

Pleomorphic effects of three small-molecule inhibitors on transcription elongation by

Omar Herrera-Asmat, Alexander B Tong, Wenxia Lin, Tiantian Kong, Juan R Del Valle, Daniel G Guerra, Yon W Ebright, Richard H Ebright, Carlos Bustamante

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Omar Herrera-Asmat *Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-7965-444X
Alexander B Tong *Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0003-3793-2533
Wenxia LinCalifornia Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, United States.
Tiantian KongDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, China.
Juan R Del ValleDepartment of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, United States.ORCID https://orcid.org/0000-0002-8315-5264
Daniel G GuerraLaboratorio de Moléculas Individuales, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0002-2410-722X
Yon W EbrightWaksman Institute, Rutgers University, New Brunswick, United States.
Richard H EbrightWaksman Institute, Rutgers University, New Brunswick, United States.ORCID https://orcid.org/0000-0001-8915-7140
Carlos BustamanteJason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-2970-0073

Funding

TRANSCRIPTION ACTIVATION BY CAPR01GM041376 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI RICHARD H. EBRIGHT · 1989 to 2026
$6.5M
THE PHYSICAL CHEMISTRY OF NUCLEIC ACIDSR01GM032543 · NIGMS · UNIVERSITY OF OREGON · PI CARLOS Jose BUSTAMANTE · 1985 to 2026
$6.4M
BACTERIAL TRANSCRIPTION COMPLEXESR37GM041376 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI EBRIGHT, RICHARD H. · 2013 to 2022
$5.0M
PHYSICAL CHEMISTRY OF NUCLEIC ACIDSR37GM032543 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUSTAMANTE, CARLOS JOSE · 1999 to 2008
$2.4M
National Natural Science Foundation of China 31900883NIGMS NIH HHS R01 GM032543NIGMS NIH HHS R01 GM041376NIGMS NIH HHS R37 GM032543NIGMS NIH HHS R37 GM041376NIH HHS GM041376NIH HHS R01GM032543
6 · The paper itself

Abstract

The

Indexed as

Antitubercular AgentsBacterial ProteinsDNA-Directed RNA PolymerasesEnzyme InhibitorsMycobacterium tuberculosisTranscription Elongation, GeneticEscherichia coliAntitubercular AgentsBacterial ProteinsDNA-Directed RNA PolymerasesEnzyme Inhibitorsantibioticsbiochemistrychemical biologyE. colimolecular biophysicsM. tuberculosisoptical tweezerssingle molecule biophysicsstructural biologytranscription

Identifiers

PMID41042133
PMCPMC12558654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.