Evidence map›Paper›PMID 41042077›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression.

Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E Rowe, Lupeng Li, Laura E Herring and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Extracellular cGAMP in health and disease.Molecular biomedicine · 2026
    Review
  3. Review
  4. cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ying WangLineberger Comprehensive Cancer Center and Curriculum in Genetic and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Yu DengLineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jianfeng ChenLineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Quentin HahnDepartment of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
David S UmbaughDepartment of Medicine, Duke University, Durham, NC, 27710, USA.
Zhigang ZhangLineberger Comprehensive Cancer Center, Department of Microbiology and Immunology and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Yanqiong ZhangLineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sarah E RoweDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Lupeng LiDepartment of Integrative Immunobiology, Duke University, Durham, NC, 27710, USA.
Laura E HerringUNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Brian P ConlonDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Edward A MiaoDepartment of Integrative Immunobiology, Department of Molecular Genetics and Microbiology, Department of Pathology and Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Blossom DamaniaLineberger Comprehensive Cancer Center, Department of Microbiology and Immunology and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Anna Mae DiehlDepartment of Medicine, Duke University, Durham, NC, 27710, USA.
Pengda LiuLineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID https://orcid.org/0000-0003-2755-3601

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Elucidating novel functions of cGAS in breast cancerR01CA244825 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, PENGDA · 2020 to 2024
$1.8M
Mary Kay Ash FoundationNCI Center Core Support CA16086NCI NIH HHS P01 CA019014NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA244825NIH HHS CA244825NIH R01 CA019014NIH R01 CA291473University of North Carolina at Chapel Hill University Cancer Research Fund
6 · The paper itself

Abstract

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor essential for host defense against microbial infections, but its role beyond innate immunity remains unclear. Here, a non-canonical function of cGAS in regulating aldehyde metabolism and lipid homeostasis is identified. This is demonstrated that cGAS directly binds to and suppresses ALDH2 (aldehyde dehydrogenase 2), a key enzyme in ethanol metabolism and lipid peroxidation. Loss of cGAS activates ALDH2, thereby enhancing ethanol tolerance in mice. Elevated ALDH2 activity upon cGAS loss increases aldehyde conversion into acetyl-CoA, promoting histone acetylation and transcription of lipid synthesis genes, which drives lipid droplet accumulation in cells and in cGas

Indexed as

Aldehyde Dehydrogenase, MitochondrialFatty LiverLipid DropletsNucleotidyltransferasesAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease ProgressionEndoplasmic Reticulum StressHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanALDH2 protein, mousecGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseNucleotidyltransferasesALDH2cGASHFDlipid dropletsMASLD

Identifiers

PMID41042077
PMCPMC12697864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.