Evidence map›Paper›PMID 41042058›Full record

SynthesisMicrosurgery2025

Liposomal Bupivacaine in Transversus Abdominis Plane Block for Postoperative Pain Control After Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis.

Victor F A Almeida, Glaudir Donato, Andressa Alves de Carvalho, Wanessa Alves de Carvalho, Ammar Lakda, Yara Dias, Manoela Dantas, Pedro Danielian, Eliana F R Duraes

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Microsurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor F A AlmeidaDepartment of Anesthesiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-8513-2827
Glaudir DonatoCenter of Medical Sciences, Federal University of Paraíba, João Pessoa, Brazil.ORCID https://orcid.org/0000-0001-8081-9734
Andressa Alves de CarvalhoInternal Medicine Department, Hospital Universitário Lauro Wanderley, João Pessoa, Brazil.ORCID https://orcid.org/0000-0003-2828-479X
Wanessa Alves de CarvalhoSurgery Department, Hospital Universitário Lauro Wanderley, João Pessoa, Brazil.ORCID https://orcid.org/0000-0002-4507-8149
Ammar LakdaDepartment of Anesthesiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Yara DiasDepartment of Anesthesiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Manoela DantasDigestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0009-8022-7902
Pedro DanielianDepartment of Hematology and Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-8893-071X
Eliana F R DuraesDepartment of Plastic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3369-127X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous breast reconstruction using abdominally based flaps is common post-mastectomy, but donor-site pain often leads to prolonged opioid use. The transversus abdominis plane (TAP) block is a common regional anesthesia technique, with bupivacaine as the standard anesthetic. Liposomal bupivacaine (LB), a prolonged-release formulation, aims to extend pain relief and reduce opioid consumption, though its efficacy remains debated.

objectiveThis systematic review and meta-analysis compared LB versus plain bupivacaine (PB) in TAP blocks for autologous breast reconstruction, focusing on opioid consumption, pain scores, and hospital stay.

methodsA systematic search identified randomized controlled trials and observational studies comparing LB (with or without PB) to PB in TAP blocks. Data were pooled using a random-effects model (I

resultsSix studies (429 patients) met inclusion criteria. LB was associated with significant reduction in opioid consumption on postoperative days (POD) 1 (MD = -4.99 mg; 95% CI: [-8.42; -1.56], p < 0.01, I

conclusionLB reduced opioid consumption during the first 48 h postoperatively and modestly improved pain control on POD 2 and POD 3, but did not shorten hospital stay. Further large-scale RCTs are needed to validate its benefits.

Indexed as

Anesthetics, LocalBupivacaineMammaplastyNerve BlockPain ManagementPostoperative PainAbdominal MusclesFemaleHumansLiposomesMastectomyPain MeasurementRandomized Controlled Trials as TopicAnesthetics, LocalBupivacaineLiposomesautologous breast reconstructionliposomal bupivacaineopioid consumptionpain managementplain bupivacaineTAP block

Identifiers

PMID41042058
PMCPMC12493009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.