Evidence map›Paper›PMID 41041978›Full record

ArticleJournal of cellular physiology2025

The Role of GPR39 in Regulating Osteoblast Function, Bone Matrix Quality, and Gender-Specific Bone Homeostasis.

Biplab Chaterjee, Gal Gozlan, Chen Abramovitch-Dahan, Anton Davydok, Anat Reiner-Benaim, Johannes Krug, Katharina Jähn-Rickert, Björn Busse, Noam Levaot

Abstract read
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In one paragraph

Article in Journal of cellular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Biplab ChaterjeeDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Gal GozlanDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Chen Abramovitch-DahanDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Anton DavydokInstitute of Material Physics, Hereon Outstation at DESY, Helmholtz Zentrum Hereon, Hamburg, Germany.
Anat Reiner-BenaimDepartment of Epidemiology, Biostatistics and Community Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Johannes KrugDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Katharina Jähn-RickertDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Björn BusseDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Noam LevaotDepartment of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID 0000-0001-7747-3883

Funding

This work was supported by grants from the Israel Science Foundation No. 357/18 (N.L.) and Deutsche Forschungsgemeinschaft (DFG) No. BU2562/12 (N.L. and B.B.).
6 · The paper itself

Abstract

GPR39, a zinc-sensing receptor, is essential for bone homeostasis in male mice through regulation of osteoblast function and matrix composition. This study examined the effects of GPR39 deficiency in female mice using both global and osteoblast lineage-specific GPR39 knockout models (Gpr39

Indexed as

Bone and BonesBone MatrixOsteoblastsReceptors, G-Protein-CoupledAnimalsBone RemodelingCalcification, PhysiologicCollagen Type IFemaleHomeostasisMaleMiceMice, KnockoutOsteogenesisOsteoporosisSignal TransductionCollagen Type IGPR39 protein, mouseReceptors, G-Protein-CoupledZincbone compositionbone mineralizationCol1a2collagencollagen depositionosteoblastsosteoporosisovariectomyzincZnR/GPR39

Identifiers

PMID41041978
PMCPMC12492777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.