Evidence map›Paper›PMID 41041970›Full record

ArticleJournal of psychosocial oncology2026

Social wellbeing, loneliness, and symptom burden in head and neck cancer survivors: a latent class analysis.

Eden R Brauer, Kristen R Choi, Laura Petersen, Patricia A Ganz, Maie A St John, Deborah J Wong, Emily J Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosocial oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eden R BrauerSchool of Nursing, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Kristen R ChoiSchool of Nursing, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Laura PetersenDepartment of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Patricia A GanzDepartment of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Maie A St JohnMultidisciplinary Head and Neck Cancer Program, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Deborah J WongMultidisciplinary Head and Neck Cancer Program, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Emily J MartinMultidisciplinary Head and Neck Cancer Program, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Funding

Harnessing the EHR for the Delivery of Supportive Care in an Oncology SettingK08CA252615 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAUER, EDEN R. · 2021 to 2025
$934k
NCI NIH HHS K08 CA252615
6 · The paper itself

Abstract

purposeTo identify patterns of co-occurring symptoms in a sample of head and neck cancer (HNC) survivors; compare symptom burden among latent classes; and examine associations between symptom classes and social wellbeing outcomes.

methodsThis cross-sectional survey of HNC survivors ≥1 year post-diagnosis was conducted in 2020 using a tumor registry at an academic medical center. Primary outcomes were loneliness and activities impairment. Participants reported 19 HNC-specific symptoms using the European Organization for Research and Treatment of Cancer HNC module (EORTC HN-43), and general cancer symptoms (sleep, pain, anxiety, depression, fatigue). Latent class analysis was used to identify subgroups with different symptom patterns. Multivariable regression models were estimated to examine associations between class membership and social wellbeing outcomes.

findingsThree hundred forty-seven survivors (mean age 65.5 ± 11.3 years; 3.72 ± 2.3 years post-diagnosis) completed the survey. Participants were predominantly male (72.6%), White (81.6%), and under age 65 years at diagnosis (59.4%). Three symptom classes were identified: (1) complex symptom burden (45%), (2) oral/sensory symptom dominant (38.9%), and (3) limited symptom impact (15.8%). Membership in the complex symptom burden class was associated with increased activity impairment (

conclusionElevated and complex HNC symptom burden is associated with higher levels of general cancer symptoms and risk for loneliness and reduced engagement in daily activities. Tailored survivorship care models addressing symptom profiles of HNC survivors, particularly those with complex symptom burden, are needed to improve quality of life.

Indexed as

Cancer SurvivorsHead and Neck NeoplasmsLonelinessAgedCross-Sectional StudiesFemaleHumansLatent Class AnalysisMaleMiddle AgedQuality of LifeSymptom BurdenCancer survivorshiphead and neck cancerlonelinesssocial wellbeingsymptom clusters

Identifiers

PMID41041970
PMCPMC12596751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.