Evidence map›Paper›PMID 41041964›Full record

ArticleActa ophthalmologica2026

Exploring ocular fundus morphology in relation to growth in adolescents born moderate-to-late preterm.

Alexandra Lind, Sara Ali, Titus Ovik, Zoran Popovic, Eva Aring, Jovanna Dahlgren, Marita Andersson Grönlund

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In one paragraph

Article in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra LindDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-7784-0521
Sara AliDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Titus OvikDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0009-0005-7736-3277
Zoran PopovicDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-5616-9847
Eva AringDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Jovanna DahlgrenDepartment of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Marita Andersson GrönlundDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-6298-360X

Funding

ALF agreement between the Swedish government and the country councils ALFGBG-11626ALF agreement between the Swedish government and the country councils ALFGBG-11869ALF agreement between the Swedish government and the country councils ALFGBG-211671ALF agreement between the Swedish government and the country councils ALFGBG-445021ALF agreement between the Swedish government and the country councils ALFGBG 509761ALF agreement between the Swedish government and the country councils ALFGBG 672501ALF agreement between the Swedish government and the country councils ALFGBG 71933ALF agreement between the Swedish government and the country councils ALFGBG-772951ALF agreement between the Swedish government and the country councils ALFGBG-932558ALF agreement between the Swedish government and the country councils ALGBG-719711Göteborgs LäkaresällskapSwedish Research SocietyThe Foundation De Blindas VännerW. & M. Lundgren Vetenskapsfond II
6 · The paper itself

Abstract

purposeTo study ocular fundus morphology and its relation to growth in adolescents born moderate-to-late preterm (MLP) and full term.

methodsThis prospective and population-based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full-term controls (30 girls, mean age 16.7 years). Optical coherence tomography measurements were studied in relation to gestational age, auxological data, insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3).

resultsThe MLP group showed an increased central macular retinal thickness (MRT) compared with controls in right eye (RE) (249.7 ± 21.0 vs. 239.9 ± 16.4 μm, p = 0.019). Moreover, the MLP group showed a thinner total peripapillary retinal nerve fibre layer (ppRNFL) thickness in RE (104.3 ± 8.5 vs. 109.1 ± 8.3, p = 0.0011). Nasal ppRNFL thickness was thinner in both RE (79.4 ± 13.2 vs. 85.0 ± 10.8, p = 0.0012) and left eye (LE) (77.0 ± 13.8 vs. 81.7 ± 13.4, p = 0.025) compared with controls. A weak association between total ppRNFL thickness and IGF-I levels was found (RE, r = 0.28, p = 0.032; LE, r = 0.27, p = 0.048), as well as between central MRT and a ratio between IGF-I and IGFBP-3 levels (RE, r = 0.30, p = 0.022). Additionally, there was a correlation between optic cup/disc area ratio and birth weight (RE: r = -0.44, p = 0.0006; LE: r = -0.30, p = 0.026).

conclusionThe present study suggests that growth and MLP birth may impact ocular fundus morphology. The MLP adolescents were shown to have thinner ppRNFL thickness and greater MRT, compared with full-term controls. Furthermore, a weak association between these structures and growth factors was found. In addition, the current study proposes that birth weight may impact optic disc parameters.

Indexed as

Infant, PrematureRetinal Ganglion CellsTomography, Optical CoherenceAdolescentFemaleFollow-Up StudiesFundus OculiGestational AgeHumansInfant, NewbornInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMacula LuteaMaleNerve FibersProspective StudiesInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IAdolescenceinsulin‐like growth factor‐Imacular retinal thicknessmoderate‐to‐late pretermoptical coherence tomography and retinal nerve fibre layer

Identifiers

PMID41041964
PMCPMC13058674

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