ArticleeLife2025
Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Non-invasive brain stimulation techniques have the potential to improve memory functions. However, the results so far have been relatively modest and time-consuming. Here, we implemented a novel 3-min combination of personalized repetitive transcranial magnetic stimulation (intermittent theta burst, iTBS) coupled with simultaneous application of gamma transcranial alternating current stimulation (γtACS) over the precuneus, a brain area connected with the hippocampus, to modulate long-term memory in healthy subjects. Only dual electromagnetic stimulation of the precuneus produced an increase in long-term associative memory as compared to iTBS alone and sham conditions in a sample of healthy volunteers. The effects were replicated in another independent sample, in which the increased associative memory was retained for up to 1 week. Moreover, dual stimulation increased gamma oscillations and precuneus-hippocampus functional connectivity through the white matter tracts linking the precuneus with the temporal lobe. These findings show that dual stimulation may lead neuronal assemblies in a state favorable to enhance long-term plasticity. Personalized dual electromagnetic stimulation of the precuneus may represent a new powerful approach for enhancing memory functions in several healthy and clinical conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.